ENZYMATIC O-METHYLATION OF N-ACETYLSEROTONIN TO MELATONIN
ENZYMATIC O-METHYLATION OF N-ACETYLSEROTONIN TO MELATONIN
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DOI：
10.1126/science.131.3409.1312
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发表时间：
1960-01-01
期刊：
影响因子：
56.9
通讯作者：
WEISSBACH, H
中科院分区：
文献类型：
--
作者：
AXELROD, J;WEISSBACH, H
本文描述了一种酶，即羟基吲哚-O-甲基转移酶，它能将S-腺苷蛋氨酸的甲基转移到N-乙酰5-羟色胺的羟基上，形成褪黑激素。这种高度定位于松果体的酶，也是5-羟色胺的O-甲基化产物。
An enzyme, hydroxyindole-O-methyl transferase, that can transfer the methyl group of S-adenosylmethionine to the hydroxy group of N-acetylserotonin to form the hormone melatonin is described. This enzyme, which is highly localized in the pineal gland, also O-methylates serotonin.