Patient-reported Outcomes and Quality of Life After Treatment of Choroidal Melanoma: A Comparison of Enucleation Versus Radiotherapy in 1596 Patients
Patient-reported Outcomes and Quality of Life After Treatment of Choroidal Melanoma: A Comparison of Enucleation Versus Radiotherapy in 1596 Patients
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DOI：
10.1016/j.ajo.2018.03.015
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发表时间：
2018-09-01
影响因子：
4.2
通讯作者：
Dunn, Laura B.
中科院分区：
文献类型：
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作者：
Damato, Bertil;Hope-Stone, Laura;Dunn, Laura B.
目得：为了检验这一假设，脉络膜黑色素瘤放疗患者享有更好的生活质量（QoL）比谁经历了enucleation.METHODS：在这个nonrandomized研究中，脉络膜黑色素瘤患者在皇家利物浦大学医院，利物浦，英国，被邀请完成QoL问卷调查约6个月后，然后在每个周年的主要治疗。这些工具包括欧洲癌症研究和治疗组织（EORTC）QLQ-OPT 30问卷，医院焦虑和抑郁量表和癌症治疗功能评估问卷。患者报告的结果与人口统计学，眼部治疗，社会因素，呈现肿瘤和眼部状态，自我报告的一般健康状况，婚姻状况，和employment status.RESULTS：1596例患者接受放疗（72.3%）或眼球摘除术（27.7%）。眼球摘除与男性（χ 2，P= 0.004）、年龄（t检验，P
PURPOSE: To test the hypothesis that patients treated with radiotherapy for choroidal melanoma enjoy better quality of life (QoL) than patients who have undergone enucleation.METHODS: In this nonrandomized study, patients with choroidal melanoma treated at the Royal Liverpool University Hospital, Liverpool, UK, were invited to complete QoL questionnaires approximately 6 months postoperatively and then on each anniversary of their primary treatment. These instruments consisted of the European Organization for Research and Treatment of Cancer (EORTC) QLQ-OPT30 questionnaire, Hospital Anxiety & Depression Scale, and the Functional Assessment of Cancer Treatment questionnaire. Patient-reported outcomes were correlated with demographics, ocular treatment, social factors, presenting tumor and ocular status, self-reported general health, marital status, and employment status.RESULTS: The 1596 patients were treated with radiotherapy (72.3%) or enucleation (27.7%). Enucleation was associated with male sex (chi(2), P=.004), older age (t test, P