Prenatal development of the receptive fields of individual trigeminal ganglion cells in the rat.
Prenatal development of the receptive fields of individual trigeminal ganglion cells in the rat.
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大鼠个体三叉神经节细胞感受野的产前发育。
DOI：
10.1152/jn.1993.69.4.1171
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发表时间：
1993
影响因子：
2.5
通讯作者：
Rhoades,RW
中科院分区：
文献类型：
--
作者：
Chiaia,NL;Bauer,WR;Rhoades,RW
1.采用细胞外单单位记录和感受野定位技术，对胚胎（E-）第15天和E-20天（E-0是受孕日）未麻醉、去大脑的胎鼠三叉神经节细胞的反应特征进行了评价。2.除了E-15，在所有这些年龄记录的细胞（n = 282）的感受场特性是非常相似的; V初级传入一般是沉默的，在没有外周刺激（94.3%），并迅速适应反应无害的触觉刺激（97.5%）。在14个测试细胞中的9个（64%）中观察到对重复刺激的快速反应递减。3.没有一个记录的细胞被热或冷激活。未尝试评价对有害机械刺激的反应。4.特别注意的是神经元的感受野涉及mystyrus vibrissae卵泡。在所有年龄段，神经元被记录，响应于在触须的基础上的皮肤压痕，但触须偏转是不是一个足够的刺激任何测试的细胞。在所有年龄段，几乎所有（89.0%）的127个细胞与触须相关的感受野响应一个且只有一个卵泡的压痕。5.这些结果表明，响应特性（例如，适应特性，对重复刺激的反应能力）的V初级传入在胎鼠与成年动物的V神经节细胞有很大的不同，但这些神经元在产前大鼠的感受野大小是，除了非常罕见的例外，成人一样，从最早的年龄，他们可以记录。6.这些结果，当考虑到与以前的逆行追踪实验的结果在胎儿动物，表明V初级传入的外周目标的初始预测可能是相当准确的。
1. Extracellular single-unit recording and receptive-field mapping techniques were used to evaluate the response characteristics of trigeminal (V) ganglion cells in unanesthetized, decerebrate, fetal rats between the ages of embryonic (E-) day 15 and E-20 (E-0 is the day of conception). 2. The receptive-field properties of the cells (n = 282) recorded at all of these ages except E-15 were remarkably similar; V primary afferents were generally silent in the absence of peripheral stimulation (94.3%) and gave rapidly adapting responses to innocuous tactile stimuli (97.5%). Rapid response decrements to repeated stimuli were observed in 9 of the 14 cells (64%) tested. 3. None of the cells recorded were activated by either heat or cold. No attempt was made to evaluate responses to noxious mechanical stimuli. 4. Particular attention was paid to neurons whose receptive fields involved mystacial vibrissae follicles. At all ages, neurons were recorded that responded to indentation of the skin at the base of the vibrissae, but vibrissa deflection was not an adequate stimulus for any of the cells tested. At all ages, nearly all (89.0%) of the 127 cells with vibrissa-related receptive fields responded to indentation of one and only one follicle. 5. These results indicate that the response properties (e.g., adaptation characteristics, ability to respond to repeated stimuli) of V primary afferents in fetal rats differ substantially from those of V ganglion cells in adult animals, but that the receptive-field size for these neurons in prenatal rats is, with very rare exceptions, adult-like from the earliest age at which they can be recorded. 6. These results, when considered together with the results of previous retrograde tracing experiments in fetal animals, suggest that the initial projections of V primary afferents to their peripheral targets may be quite accurate.