Mild Cognitive Impairment and Dementia Involving Multiple Cognitive Domains in Mexican Urbanites
Mild Cognitive Impairment and Dementia Involving Multiple Cognitive Domains in Mexican Urbanites
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DOI：
10.3233/jad-181208
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发表时间：
2019-01-01
影响因子：
4
通讯作者：
Villanueva-Duque, Jose A.
中科院分区：
文献类型：
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作者：
Calderon-Garciduenas, Lilian;Mukherjee, Partha S.;Villanueva-Duque, Jose A.
暴露于细颗粒物PM2.5和臭氧O-3与阿尔茨海默病（AD）风险相关。墨西哥城居民终生暴露于PM2.5和O-3，高于美国环保局的年度标准，他们的大脑含有高氧化还原，燃烧和摩擦衍生的磁铁矿纳米颗粒。AD病理学变化具有婴儿期的皮质下预缠结阶段和皮质tau蛋白预缠结、NFT阶段I-II和淀粉样蛋白阶段1-2，在第2个十年被鉴定。考虑到他们的AD连续性，可靠地识别认知障碍至关重要。蒙特利尔认知评估（莫卡）对墨西哥PM2.5污染城市的517名城市居民进行了管理，年龄为21.60 +/- 5.88岁，正规教育年限为13.69 +/- 1.28年。莫卡评分为23.92 +/- 2.82，24.7%和30.3%评分为
Exposures to fine particulate matter PM2.5 and ozone O-3 are associated with Alzheimer's disease (AD) risk. Mexico City residents have lifetime exposures to PM2.5 and O-3 above annual USEPA standards and their brains contain high redox, combustion, and friction-derived magnetite nanoparticles. AD pathological changes with subcortical pre-tangle stages in infancy and cortical tau pre-tangles, NFT Stages I-II, and amyloid phases 1-2 are identified by the 2nd decade. Given their AD continuum, a reliable identification of cognitive impairment is of utmost importance. The Montreal Cognitive Assessment (MoCA) was administered to 517 urbanites, age 21.60 +/- 5.88 years, with 13.69 +/- 1.28 formal education years, in Mexican PM2.5 polluted cities. MoCA score was 23.92 +/- 2.82, and 24.7% and 30.3% scored