Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice.
Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice.
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瑞马唑仑可预防脂多糖诱导的内毒素，提高内毒素血症小鼠的存活率
DOI：
10.3389/fphar.2021.739603
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发表时间：
2021
影响因子：
5.6
通讯作者：
Tang J
中科院分区：
文献类型：
--
作者：
Liu X;Lin S;Zhong Y;Shen J;Zhang X;Luo S;Huang L;Zhang L;Zhou S;Tang J
瑞马唑仑是一种新型苯二氮卓类镇静药物，具有超短效麻醉作用，常用于重症监护病房（ICU）的危重病人（尤其是脓毒症患者）。尽管据报道一些麻醉剂显示出一定的抗炎作用，但瑞马唑仑在炎症中的作用仍然未知。在这里，我们在体内和体外研究了瑞马唑仑对巨噬细胞响应 LPS 的影响。有趣的是，与LPS治疗组相比，瑞马唑仑显着提高了内毒素血症小鼠的存活率，并减少了LPS诱导的炎症介质（如TNF-α、IL-6和IL-1β）的释放。我们进一步发现，瑞马唑仑不仅在 LPS 处理后 15 分钟抑制 MAPK 信号通路的激活，而且在随后的时间扰乱细胞表面响应 LPS 的 Rab5a 相关 TLR4 表达。这些证据表明，瑞马唑仑可能对患有不受控制的炎症反应的脓毒症患者有益。
Remimazolam is a new benzodiazepine of sedative drugs with an ultra-short-acting anesthetic effect, commonly used for critically ill patients (especially septic patients) in intensive care units (ICUs). Although some anesthetics have been reported to show certain anti-inflammatory effects, the role of remimazolam in inflammation is still remained unknown. Here, we studied the effects of remimazolam on macrophage in response to LPS both in vivo and in vitro. Interestingly, compared with LPS treatment group, remimazolam remarkably improved survival rate of endotoxemia mice and decreased the release of LPS-induced inflammatory mediators (such as TNF-α, IL-6, and IL-1β). We further found that remimazolam not only inhibited the activation of MAPK signal pathway at 15 min after LPS treatment but also disturbed Rab5a related TLR4 expression at cell surface in response to LPS at a later time. Such evidence suggests that remimazolam might be beneficial to septic patients who are suffering from uncontrolled inflammatory responses.
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影响因子：
2.9
作者：
Li, Fei;Liu, Jian;Liu, Nan;Kuhn, Leslie A.;Garavito, R. Michael;Ferguson-Millert, Shelagh
通讯作者：
Ferguson-Millert, Shelagh
影响因子：
5.2
作者：
Ramachandran G
通讯作者：
Ramachandran G
影响因子：
4.8
作者：
Chen, Yen-Jen;Hsieh, Ming-Yu;Leu, Tzeng-Horng
通讯作者：
Leu, Tzeng-Horng
影响因子：
8.8
作者：
Kilpatrick, Gavin J.;McIntyre, Margaret S.;Tilbrook, Gary S.
通讯作者：
Tilbrook, Gary S.
影响因子：
13.5
作者：
Guilarte TR
通讯作者：
Guilarte TR