In vitro antimalarial activity of Brucea javanica against multi-drug resistant Plasmodium falciparum.
In vitro antimalarial activity of Brucea javanica against multi-drug resistant Plasmodium falciparum.
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鸦胆子对多重耐药恶性疟原虫的体外抗疟活性。
DOI：
10.1055/s-2007-969092
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发表时间：
1986
期刊：
影响因子：
2.7
通讯作者：
P. Kanchanapee
中科院分区：
文献类型：
--
作者：
K. Pavanand;W. Nutakul;T. Dechatiwongse;K. Yoshihira;K. Yongvanitchit;J. Scovill;J. Flippen;R. Gilardi;C. George;P. Kanchanapee
本文报道了药用植物野牡丹（Brucea JAVANICA（L.）Merr.（Simaroubaceae）的抗疟特性进行了检查。在果实的不同粗溶剂提取物中，氯仿提取物显示出具有最有效的体外抗疟活性。从氯仿提取物中分离纯化了三种活性化合物。通过紫外光谱、红外光谱、核磁共振谱和质谱分析，确定了这些化合物分别为马钱子碱A、马钱子碱B水合物和马钱子碱C。当针对多药耐药分离株P. ciciparum进行体外试验时，马钱子碱A和马钱子碱B水合物的活性相似（ID 50为8.66和8.15 ng/ml），而马钱子碱C的ID 50为1.95 ng/ml。这些化合物的体外活性与新的抗疟药甲氟喹相当（ID 50为6.26 ng/ml）。
The medicinal plant, BRUCEA JAVANICA (L.) Merr. (Simaroubaceae) was examined for antimalarial properties. Among different crude solvent extracts of the fruit, the chloroform extract was shown to have the most potent IN VITRO antimalarial activity. Three active compounds were isolated and purified from the chloroform extract. These compounds were confirmed as bruceine A, bruceine B hydrate and bruceine C by UV, IR, NMR and mass spectra. When tested IN VITRO against multi-drug resistant isolates of P. FALCIPARUM bruceine A and bruceine B hydrate were similar in activity (ID50 of 8.66 and 8.15 ng/ml) whereas bruceine C had an ID50 of 1.95 ng/ml. These compounds were comparable in IN VITRO activity to the new antimalarial drug, mefloquine (ID50 of 6.26 ng/ml).