Wnt signaling in stem and cancer stem cells
Wnt signaling in stem and cancer stem cells
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DOI：
10.1016/j.ceb.2013.01.004
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发表时间：
2013-04-01
影响因子：
7.5
通讯作者：
Birchmeier, Walter
中科院分区：
文献类型：
--
作者：
Holland, Jane D.;Klaus, Alexandra;Birchmeier, Walter
Wnt/β-连环蛋白信号传导的功能多功能性可以通过其在胚胎干细胞、成人干细胞以及癌症干细胞中的作用能力看出。在胚胎发生过程中，干细胞需要 β-连环蛋白来介导对 Wnt 信号传导的反应，以维持其多能状态并转变为多能状态。在成体干细胞中，Wnt 信号传导在不同的层次上发挥作用，有助于不同组织的分化。这提出了一种可能性，即干细胞和祖细胞中 Wnt 信号介导的严格调节的自我更新在癌细胞中被破坏，从而导致恶性进展。目前正在开展大量工作来解决调节 Wnt/β-连环蛋白信号传导的内在和外在因素如何协调干细胞和癌症干细胞状态。
The functional versatility of Wnt/beta-catenin signaling can be seen by its ability to act in stem cells of the embryo and of the adult as well as in cancer stem cells. During embryogenesis, stem cells demonstrate a requirement for beta-catenin in mediating the response to Wnt signaling for their maintenance and transition from a pluripotent state. In adult stem cells, Wnt signaling functions at various hierarchical levels to contribute to specification of different tissues. This has raised the possibility that the tightly regulated self-renewal mediated by Wnt signaling in stem and progenitor cells is subverted in cancer cells to allow malignant progression. Intensive work is currently being performed to resolve how intrinsic and extrinsic factors that regulate Wnt/beta-catenin signaling coordinate the stem and cancer stem cell states.