Lung clearance of particles in two strains of rats.
Lung clearance of particles in two strains of rats.
复制标题
两种大鼠品系的肺部颗粒清除率。
DOI：
10.3109/01902148009065464
复制
发表时间：
1980
影响因子：
1.7
通讯作者：
B. Morehouse
中科院分区：
文献类型：
--
作者：
J. Ferin;B. Morehouse
比较了两种常用的实验大鼠对二氧化钛颗粒的肺清除量。Fisher 344近交系大鼠在暴露7小时后保留的颗粒物可预测地少于较大的近交系Long-Evans大鼠。鉴于这两个菌株的肺大小不同，这一事实是可以预料到的。此外，在Fisher 344大鼠中，残留颗粒的清除明显较慢。在进行吸入毒理学实验时，应考虑不同动物品系的肺清除能力的差异。
Two strains of commonly used experimental rats were compared with regard to lung clearance of TiO2 particles. The Fisher 344 inbred rats retained predictably fewer particles after a 7-hr exposure than the larger outbred Long-Evans rats. This fact can be expected in view of the different lung size of the two strains. In addition, clearance of the retained particles was significantly slower in Fisher 344 rats. Differences in lung clearance capacity of different animal strains should be considered when experiments in inhalation toxicology are performed.