EFFECTS OF ADENINE-NUCLEOTIDES ON CUTANEOUS AFFERENT NERVE ACTIVITY
EFFECTS OF ADENINE-NUCLEOTIDES ON CUTANEOUS AFFERENT NERVE ACTIVITY
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DOI：
10.1111/j.1476-5381.1978.tb07764.x
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发表时间：
1978-01-01
影响因子：
7.3
通讯作者：
BLEEHEN, T
中科院分区：
文献类型：
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作者：
BLEEHEN, T
1将腺苷核苷酸三磷酸腺苷(ATP)、二磷酸腺苷(ADP)和一磷酸腺苷(AMP)以及钾、乙酰胆碱(ACh)、5-羟色胺(5-羟色胺)和缓激肽分别作用于麻醉兔耳上暴露的水泡基底部或动脉内麻醉猫的多条神经束上，观察其产生的活性。2在兔制剂中，钾和腺嘌呤核苷酸在神经纤维中产生活动。这些物质的效应是在可比的剂量范围内产生的；阈值效应是由浓度为13 mM的钾和浓度为4 mM的ADP产生的。ACh、5-羟色胺和缓激肽在相似或更高的浓度下均无活性。3在过氧化氢酶制剂中，所有受试物质都能产生神经纤维的活性。腺嘌呤核苷酸的效力相对弱于ACh、5-羟色胺或缓激肽，但比钾具有更大的效力。4腺嘌呤核苷酸对传入神经末梢或纤维具有一定的作用，与钾、乙酰胆碱、5-羟色胺和缓激肽等已知的致过敏物质相似。
1 The activity produced by the adenine nucleotides adenosine triphosphate (ATP), adenosine diphosphate (ADP) and adenosine monophosphate (AMP) and by potassium, acetylcholine (ACh), 5-hydroxytryptamine (5-HT) and bradykinin when applied to an exposed blister base on the ear of anaesthetized rabbits or intra-arterially to anaesthetized cats was investigated in multiple strands dissected from the auricular-temporal and saphenous nerves of rabbits and cats, respectively. 2 In the rabbit preparation potassium and the adenine nucleotides produced activity in the nerve fibres. The effects of these substances were produced in comparable dose ranges; threshold effects being produced by potassium at a concentration of 13 mM and by ADP at a concentration of 4 mM. ACh, 5-HT and bradykinin were inactive at similar or higher concentrations. 3 In the cat preparation all the substances tested produced activity in the nerve fibres. The adenine nucleotides were comparatively less potent than ACh, 5-HT or bradykinin, but had greater potency than potassium. 4 It was concluded that the adenine nucleotides do possess effects on afferent nerve terminals or fibres and thus resemble other known algogenic substances such as potassium, ACh, 5-HT and bradykinin.