Effect of stress and hypothalamic deafferentation on the secretion of growth hormone in the rat.
Effect of stress and hypothalamic deafferentation on the secretion of growth hormone in the rat.
复制标题
应激和下丘脑传入神经阻滞对大鼠生长激素分泌的影响。
DOI：
10.1159/000122131
复制
发表时间：
1973
影响因子：
4.1
通讯作者：
J. Ducharme
中科院分区：
文献类型：
--
作者：
R. Collu;J. Jéquier;J. Letarte;G. Leboeuf;J. Ducharme
已知应激刺激可抑制放射免疫测定的大鼠生长激素（RGH）的分泌。成年雄性大鼠组提交的三种不同类型的下丘脑deafferentation（总，不完全，或额叶）之一，暴露于乙醚和听觉应力在1周的时间间隔。乙醚和听觉应激同样有效地抑制RGH分泌的控制和额叶去传入大鼠。乙醚应激抑制了完全去传入动物的RGH值，而听觉应激使这些值保持不变; α-MT预处理阻断了乙醚应激在这些动物中的作用。这两种应激都不能改变不完全去传入大鼠已经很低的数值;戊巴比妥麻醉诱导这些动物的RGH血浆水平显著升高。RGH的基线水平显着较高的额叶去传入，并显着低于不完全去传入大鼠比对照组。这些数据似乎表明，乙醚压力是通过体液，多巴-minergic通路，而听觉压力遵循神经通路。此外，下丘脑外的影响似乎通过额叶抑制和后外侧刺激神经通路调节RGH的分泌。
Stressful stimuli are known to inhibitthe secretion of radioimmunoassayable rat growth hormone (RGH). Groups of adult male rats submitted to one of three different types of hypothalamic deafferentation (total, incomplete, or frontal) were exposed to ether and auditory stresses at 1 week intervals. Ether and auditory stresses were equally effective in inhibiting the RGH secretion in controls and frontally deafferented rats. Ether stress inhibited the RGH values of completely deafferented animals, while auditory stress left these values unchanged; α-MT pretreatment blocked the effect of ether stress in such animals. Neither stress was able to modify the already low values of the incompletely deafferented rats; pentobarbital anesthesia induced a marked rise of RGH plasma levels in these animals. Base-line levels of RGH were significantly higher in frontally deafferented, and significantly lower in incompletely deafferented rats than those of controls. These data seem to indicate that ether stress is transmitted through a humoral, dopa-minergic pathway, while auditory stress follows a nervous pathway. In addition, extra-hypothalamic influences seem to modulate the secretion of RGH through frontal inhibitory and postero-lateral stimulatory nervous pathways.