Humoral immunity due to long-lived plasma cells
Humoral immunity due to long-lived plasma cells
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DOI：
10.1016/s1074-7613(00)80541-5
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发表时间：
1998-03-01
期刊：
影响因子：
32.4
通讯作者：
Ahmed, R
中科院分区：
文献类型：
--
作者：
Slifka, MK;Antia, R;Ahmed, R
传统的模型表明，长期抗体应答是通过记忆B细胞持续分化为分泌抗体的浆细胞来维持的。这是基于浆细胞寿命短，需要不断地由记忆B细胞补充的概念。我们通过跟踪LCMV特异性抗体的持久性和记忆B细胞体内耗竭后的浆细胞数量以及通过将病毒特异性浆细胞过继转移到幼稚小鼠中来研究浆细胞寿命的问题。结果表明，在没有任何可检测的记忆B细胞的情况下，相当一部分浆细胞可以存活并继续分泌抗体延长的时间段（>1年）。这项研究证明了长寿浆细胞的存在，并证明了一种维持体液免疫的新机制。
Conventional models suggest that long-term antibody responses are maintained by the continuous differentiation of memory B cells into antibody-secreting plasma cells. This is based on the notion that plasma cells are short-lived and need to be continually replenished by memory B cells. We examined the issue of plasma cell longevity by following the persistence of LCMV-specific antibody and plasma cell numbers after in vivo depletion of memory B cells and by adoptive transfer of virus-specific plasma cells into naive mice. The results show that a substantial fraction of plasma cells can survive and continue to secrete antibody for extended periods of time (>1 year) in the absence of any detectable memory B cells. This study documents the existence of long-lived plasma cells and demonstrates a new mechanism by which humoral immunity is maintained.