Anti-inflammatory agents and cognitive decline in a bi-racial population
Anti-inflammatory agents and cognitive decline in a bi-racial population
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DOI：
10.1159/000115749
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发表时间：
2008-01-01
影响因子：
5.7
通讯作者：
Evans, Denis A.
中科院分区：
文献类型：
--
作者：
Grodstein, Francine;Skarupski, Kimberly A.;Evans, Denis A.
在一项涉及4409名65岁以上受试者的前瞻性研究中，我们评估了非甾体抗炎药（NSAIDs）与认知的关系。主要结果是整体认知功能的下降，这是由四次认知测试的平均表现决定的，超过四次访谈。我们发现，近期服用阿司匹林和其他非甾体抗炎药（主要是布洛芬）的患者的认知能力下降率与未服用这些非甾体抗炎药的患者相似。对于终生服用阿司匹林，我们没有发现它与认知能力下降有关。然而，对于其他非甾体抗炎药，相对于不使用其他非甾体抗炎药（5年以上vs.不使用：平均差异= 0.12；p趋势= 0.03），终生使用时间的增加与认知能力下降速度的减慢有关。总的来说，我们发现定期服用阿司匹林和认知能力下降之间没有关系，但长期服用布洛芬可能与老年人认知能力下降率的降低有关。版权所有(c) 2008 S. Karger AG，巴塞尔。
In a prospective study among 4,409 subjects aged 65+ years, we assessed the relation of nonsteroidal anti-inflammatory agents (NSAIDs) to cognition. The main outcome was decline in global cognitive function, determined by average performance across four cognitive tests, over up to four interviews. We found similar rates of cognitive decline among recent users of aspirin and of other NSAIDs (largely ibuprofen) compared to those who did not use these NSAIDs. For lifetime duration of aspirin use, we failed to find an association with cognitive decline. However, for other NSAIDs, increasing duration of lifetime use was related to slower rates of cognitive decline, relative to no use of other NSAIDs (5+ years vs. no use: mean difference = 0.12; p trend = 0.03). Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons. Copyright (c) 2008 S. Karger AG, Basel.