Cardiovascular risk factors associated with age-related macular degeneration: the Tromso Study
Cardiovascular risk factors associated with age-related macular degeneration: the Tromso Study
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DOI：
10.1111/aos.12346
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发表时间：
2014-11-01
影响因子：
3.4
通讯作者：
Njolstad, Inger
中科院分区：
文献类型：
--
作者：
Erke, Maja G.;Bertelsen, Geir;Njolstad, Inger
目的 探讨心血管危险因素与年龄相关性黄斑变性 (AMD) 之间的关联。方法 2007/2008 年在挪威对 65-87 岁白种人进行了一项基于人群的横断面研究。视网膜照片针对 AMD 进行分级。根据有关吸烟、饮酒、体力活动、健康和药物习惯的调查问卷进行多变量逻辑回归分析；体格检查，包括人体测量、血压和血液采样。心血管疾病状态是从经过验证的终点登记处获得的。结果 2631 名参与者可获得可分级照片，其中 92 名 (3.5%) 受试者患有晚期 AMD。在晚期 AMD 的多变量分析中，发现性别与年龄、甘油三酯水平、降脂药物的使用和体育锻炼等变量之间存在显着的相互作用。与从不吸烟者相比，目前每日吸烟与男女晚期 AMD 均显着相关（女性和男性的比值比 (OR) 4.06，95% 置信区间 (CI) 1.69-9.76；OR 3.59，95% CI 1.17-11.04）。较高的包装年数与大玻璃膜疣 (>125m) 的存在相关（OR 1.04，95% CI 1.01-1.09 每 5 年）。较高的收缩压（OR 1.06，95% CI 1.01-1.12/5mmHg）、超重（OR 2.87，95% CI 1.13-7.29）和肥胖（OR 2.92，95% CI 1.06-8.03）、体育锻炼持续时间（OR 0.41，95% CI 1.18-0.96） 30 分钟或更长与更少）和频率（OR 0.46，95% CI 0.23-0.92 每周或更多频率与更少）仅与女性晚期 AMD 相关。结论 吸烟与 AMD 密切相关，与其他人群的结果一致。此外，晚期 AMD 与女性较高的收缩压、缺乏身体活动、超重和肥胖有关。
PurposeTo examine associations between cardiovascular risk factors and age-related macular degeneration (AMD).MethodsA population-based, cross-sectional study of Caucasians aged 65-87years was conducted in Norway in 2007/2008. Retinal photographs were graded for AMD. Multivariable logistic regression analyses were performed based on questionnaires addressing habits of smoking, alcohol consumption, physical activity, health and medication; and physical examination comprising anthropometric measurements, blood pressure and blood sampling. Cardiovascular disease status was obtained from a validated end-point registry.ResultsGradable photographs were available for 2631 participants, of whom 92 (3.5%) subjects had late AMD. In the multivariable analysis of late AMD, significant interactions were found between sex and the variables age, triglyceride level, use of lipid-lowering drugs and physical exercise. Current daily smoking was significantly related to late AMD in both sexes (odds ratio (OR) 4.06, 95% confidence interval (CI) 1.69-9.76 and OR 3.59, 95% CI 1.17-11.04, women and men, respectively) compared with never smokers. Higher number of pack years was associated with the presence of large drusen (>125m) (OR 1.04, 95% CI 1.01-1.09 per 5years). Higher systolic blood pressure (OR 1.06, 95% CI 1.01-1.12 per 5mmHg), overweight (OR 2.87, 95% CI 1.13-7.29) and obesity (OR 2.92, 95% CI 1.06-8.03), physical exercise duration (OR 0.41, 95% 0.18-0.96 for 30min or more compared with less) and frequency (OR 0.46, 95% CI 0.23-0.92 for weekly or more often compared to less) were associated with late AMD in women only.ConclusionsSmoking was strongly associated with AMD, in line with results from other populations. Also, late AMD was related to higher systolic blood pressure, physical inactivity, overweight and obesity in women.