Thyrotropin-releasing hormone—CNS action to stimulate gastric acid secretion
Thyrotropin-releasing hormone—CNS action to stimulate gastric acid secretion
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促甲状腺激素释放激素——中枢神经系统刺激胃酸分泌的作用
作者：
Y. Taché;W. Vale;Marvin R. Brown
尽管对脑中启动或调节胃分泌的神经化学介质了解甚少，但已积累了许多生理学和药理学证据，表明胃神经系统在胃分泌的外周调节中具有重要作用1 -4。最近，一些存在于哺乳动物脑中的寡肽在中枢神经系统（CNS）中起作用以深刻地影响葡萄糖调节5、体温调节6，7、血压8，9、交感神经流出9 -11、肠道肌肉活动12的证明，13、压力--诱导的胃出血性病变14使我们研究了这些内源性脑寡肽中的一些作为参与胃出血性病变的化学信使的可能作用。胃分泌的CNS调节。我们在这里报告促甲状腺激素释放激素（TRH）的行为在中枢神经系统引起迷走神经依赖性刺激胃酸分泌。
Much physiological and pharmacological evidence has accumulated to suggest that the autonomie nervous system has an important role in the peripheral modulation of gastric secretion1, although the neurochemical mediators in the brain which initiate or modulate autonomie input are poorly understood1–4. Recently, the demonstration that some oligopeptides present in mammalian brain act in the central nervous system (CNS) to influence profoundly glucoregulation5, thermoregulation6,7, blood pressure8,9, sympathetic outflow9–11, muscular activity of gut12,13 and stress-induced gastric haemorrhagic lesions14 have led us to examine a possible role for some of these endogenous brain oligopeptides as chemical messengers involved in the CNS modulation of gastric secretion. We report here that thyrotropin-releasing hormone (TRH) acts within the CNS to elicit a vagus-dependent stimulation of gastric acid secretion.