Matrices containing NaCMC and HPMC 2. Swelling and release mechanism study
Matrices containing NaCMC and HPMC 2. Swelling and release mechanism study
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DOI：
10.1016/j.ijpharm.2006.11.067
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发表时间：
2007-03-21
影响因子：
5.8
通讯作者：
Vergnault, G.
中科院分区：
文献类型：
--
作者：
Conti, S.;Maggi, L.;Vergnault, G.
本研究的目的是研究含有羟丙基甲基纤维素（HPMC）和羧甲基纤维素钠（NaCMC）的混合物的基质系统与模型可溶性药物的溶胀行为，以找到形态行为与药物释放性能之间的相关性。在三种不同pH下，对仅含药物和两种聚合物混合物（MB）的片剂以及含每种聚合物和相同药物的参比片剂进行溶胀研究。NIB基质在pH 4.5和6.8下显示出相似的溶胀趋势，而它们在酸性流体中具有不同的行为。在pH I下，由NaCMC形成的凝胶层的特征在于部分化学交联的水凝胶的刚性结构，而HPMC和MB基质形成物理非交联的凝胶。在pH 4.5和6.8时，所有系统均显示出可溶胀基质的典型形态学行为，其中凝胶网络中的大分子链通过弱键合（物理凝胶）保持在一起。在这些缓冲液中，NIB系统保持恒定的药物释放速率，耦合扩散和侵蚀机制：凝胶和渗透层厚度保持恒定，并且可以实现零级释放动力学。(c)2006 Elsevier B.V.保留所有权利。
The aim of the present study is an investigation of the swelling behaviour of matrix systems containing a mixture of hydroxypropylmethylcellulose (HPMC) and sodium carboxymethylcellulose (NaCMC) with a model soluble drug to find the correlation between the morphological behaviour and the drug release performance. The swelling study was conducted on tablets containing only the drug and the two polymers mixture (MB) and on reference tablets containing each polymer and the same drug, at three different pHs. NIB matrices show a similar swelling trend at pH 4.5 and 6.8, while they have different behaviour in acidic fluid. At pH I the gel layer formed by NaCMC is characterized by a rigid structure of a partially chemically crosslinked hydrogel while HPMC and MB matrices form a physical not crosslinked gel. At pH 4.5 and 6.8, all the systems show the typical morphological behaviour of a swellable matrix in which the macromolecular chains in the gel network are held together by weak bondings (physical gel). In these buffers, NIB systems maintain a constant drug release rate coupling diffusion and erosion mechanism: the gel and infiltrated layers thicknesses are maintained constant and a zero-order release kinetics can be achieved. (c) 2006 Elsevier B.V. All rights reserved.