The use of magnetic resonance imaging to predict ACL graft structural properties.
The use of magnetic resonance imaging to predict ACL graft structural properties.
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DOI：
10.1016/j.jbiomech.2011.09.004
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发表时间：
2011-11-10
影响因子：
2.4
通讯作者：
Murray MM
中科院分区：
文献类型：
--
作者：
Fleming BC;Vajapeyam S;Connolly SA;Magarian EM;Murray MM
核磁共振成像(MRI)可用于无创性预测重建后前交叉韧带移植物的强度。我们假设，MRI测量的前交叉韧带的体积和T2松弛参数可以预测重建膝关节的结构特性和前后松弛。对9只山羊进行了前交叉韧带重建，方法是使用自体髌腱移植，并添加胶原或胶原-血小板复合材料。在愈合6周后，动物被实施安乐死，重建的膝盖被取回并在3T扫描仪上成像。在解剖股骨-移植物-胫骨结构之前测量AP松弛，然后进行拉伸破坏测试以确定结构特性。回归分析表明，移植物体积和失效载荷之间存在统计学上的显著关系(R2=0.502；p=0.049)。当移植物体积归一化为T2松弛时间时，这种关系更大(R2=0.687；p=0.011)。移植物体积与线硬度有显著相关性(r2=0.847；p<；0.001)，经T2归一化后仍有显著意义(r2=0.764；p=0.002)。屈曲30°时AP松弛程度与移植物体积无明显相关性，但与T2松弛时间归一化的移植物体积有显著相关性(R2=0.512；p=0.046)。这些结果表明，MRI体积测量结合移植物T2特性可能有助于预测前交叉韧带移植物的结构特性。
Magnetic Resonance Imaging (MRI) could potentially be used to non-invasively predict the strength of an ACL graft after ACL reconstruction. We hypothesized that the volume and T2 relaxation parameters of the ACL graft measured with MRI will predict the graft structural properties and anteroposterior (AP) laxity of the reconstructed knee. Nine goats underwent ACL reconstruction using a patellar tendon autograft augmented with a collagen or collagen-platelet composite. After six weeks of healing, the animals were euthanized, and the reconstructed knees were retrieved and imaged on a 3T scanner. AP laxity was measured prior to dissecting out the femur-graft-tibia constructs which were then tested to tensile failure to determine the structural properties. Regression analysis indicated a statistically significant relationship between the graft volume and the failure load (r2=0.502; p=0.049). When graft volume was normalized to the T2 relaxation time, the relationship was even greater (r2=0.687; p=0.011). There was a significant correlation between the graft volume and the linear stiffness (r2=0.847; p<0.001), which remained significant with T2 normalization (r2=0.764; p=0.002). For AP laxity at 30° flexion, there was not a significant correlation with graft volume, but there was a significant correlation with volume normalized by the T2 relaxation time (r2=0.512; p=0.046). These results suggest that MRI volumetric measures combined with graft T2 properties may be useful in predicting the structural properties of ACL grafts.
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