PROSPECTIVE-STUDY OF CONGENITAL CYTOMEGALOVIRUS-INFECTION
PROSPECTIVE-STUDY OF CONGENITAL CYTOMEGALOVIRUS-INFECTION
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DOI：
10.1097/00007611-198005000-00012
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发表时间：
1980-01-01
影响因子：
1.1
通讯作者：
SOUTH, MA
中科院分区：
文献类型：
--
作者：
MONTGOMERY, JR;MASON, EO;SOUTH, MA
新生儿尿巨细胞病毒（CMV）排泄的总发生率为954例的0.9%。低社会经济群体的发病率是高社会经济群体（SEG）的两倍。下SEG地区巨细胞病毒感染婴儿的母亲报告了更多的慢性和妊娠医学问题，并且显示出比上SEG地区巨细胞病毒感染婴儿的母亲更低的平均年龄。cmv感染婴儿的母亲的平均年龄在SEG上、下两方面与对照组没有显著差异。在9例前瞻性病例和2例转诊病例中，没有免疫反应受损。虽然9例前瞻性病例中有8例在出生时可能被认为是无症状的，但在新生儿期的仔细评估显示，5例婴儿明显生长抑制，7例婴儿有特异性临床变化，9例婴儿均有非特异性临床变化。因此，“无症状”的新生儿可能在新生儿期表现出感染的影响。
The overall incidence of neonates with urinary cytomegalovirus (CMV) excretion was 0.9% of 954 tested. The incidence was twice as high in the lower as in the upper socioeconomic group (SEG). Mothers of infants with CMV infection in the lower SEG reported a greater number of chronic and gestational medical problems and showed a lower mean age than mothers of CMV-infected infants in the upper SEG. The mean age of mothers of CMV-infected infants was not significantly different from the respective control group in either upper or lower SEG. There was no impairment of immune responses in nine prospective or in two referred cases. Although eight of nine prospective cases might have been considered asymptomatic at birth, careful evaluation in the neonatal period showed significant growth inhibition in five, specific clinical changes in seven, and nonspecific clinical changes in all of the nine infants. Thus," asymptomatic" neonates may demonstrate effects of the infection during the neonatal period.