Di(2-ethythexyl)phthalate: lack of initiating activity in the liver of female F-344 rats
Di(2-ethythexyl)phthalate: lack of initiating activity in the liver of female F-344 rats
复制标题
邻苯二甲酸二(2-乙基己酯)：雌性 F-344 大鼠肝脏缺乏起始活性
DOI：
10.1093/carcin/8.2.285
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发表时间：
1987
期刊：
影响因子：
4.7
通讯作者：
J. Popp
中科院分区：
文献类型：
--
作者：
L. K. Garvey;J. Swenberg;Thomas E. Hammn;J. Popp
邻苯二甲酸二（2-乙基己基）酯（DEHP）是一种过氧化物酶体增殖剂，在国家毒理学计划2年生物测定中对雌性大鼠具有致癌性。然而，当使用相同性别和品系的大鼠以及导致肝癌的给药方案进行测试时，DEHP的促进活性为阴性。过氧化物酶体增殖物的致癌反应可能与细胞中活性氧的过量产生有关。鉴于这一点和负面促进数据，在单次和亚慢性给药后检查了DEHP的起始活性。当DEHP以单次口服剂量（10 g/kg）给药或以1.2%的膳食浓度喂养12周后，随后进行促进方案时，未发现启动活性。当使用多种组织学标记物检查肝脏切片时，病灶的数量或平均体积没有增加，并且没有发现肿瘤。
Di(2-ethylhexyl)phthalate (DEHP) is a peroxisome proliferator that was hepatocarcinogenic in female rats in a National Toxicology Program 2-year bioassay. However, DEHP was negative for promotional activity when tested using the same sex and strain of rat and dosing regimen that resulted in hepatocarcinogenicity. The carcinogenic response of peroxisome proliferators may be related to excess production of reactive oxygen species in the cell. In view of this and the negative promotion data, the initiating activity of DEHP was examined after single and sub-chronic dosing. No initiating activity was found when DEHP was administered in a single, oral dose (10 g/kg) or after 12 weeks of feeding at a dietary concentration of 1.2% when each was followed by a promotion regimen. There was no increase in number or mean volume of foci when liver sections were examined using multiple histologic markers and no tumors were identified.