Association of BMP-14 rs143383 ploymorphism with its susceptibility to osteoarthritis: A meta-analysis and systematic review according to PRISMA guideline.
Association of BMP-14 rs143383 ploymorphism with its susceptibility to osteoarthritis: A meta-analysis and systematic review according to PRISMA guideline.
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DOI：
10.1097/md.0000000000007447
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发表时间：
2017-10
期刊：
影响因子：
1.6
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Yin Y;Wang Y
骨关节炎（OA）是一种复杂的疾病，可由环境和遗传因素引起。骨形态发生蛋白-14（BMP-14）的功能位点rs143383已被指出与OA病因学相关，但已得出相互矛盾的结论。为了提供关于这个问题的更全面的结论，我们进行了这项荟萃分析。从PubMed、Chinese National Knowledge Infrastructure、Embase和Wanfang等电子数据库检索相关研究。相关性的强度用合并的比值比（OR）和95%置信区间（95% CI）进行检查。进行了按种族和控制来源分层的亚组分析。所有统计分析均采用STATA软件（版本12.0）进行。总体而言，在CC与TT、CC + TC与TT、CC与TT + TC、C与T、TC与TT的遗传对比下，BMP-14 rs143383多态性与膝OA和手OA的易感性呈负相关（OR = 0.71，95% CI = 0.65-0.79; OR = 0.81，95% CI = 0.73-0.89; OR = 0.79，95% CI = 0.71-0.86; OR = 0.85，95% CI = 0.81-0.90; OR = 0.84，95%CI = 0.75 - 0.93），以及TC与TT、CC与TT + TC、C与T（OR = 0.76，95% CI = 0.65-0.89; OR = 0.79，95% CI = 0.68-0.92; OR = 0.90，95%CI = 0.85 - 0.95）;分层分析后，在亚组中观察到相似的结果。 此外，在按种族分层分析后，该多态性也降低了亚洲组髋关节OA的风险。BMP-14 rs143383多态性可能是OA发生的保护因素。
Osteoarthritis (OA) is a complex disease which can be caused by both environmental and genetic factors. A functional locus rs143383 of bone morphogenetic protein-14 (BMP-14) has been pointed out to be associated with OA etiology, but conflicting conclusions have been reached. To provide a more comprehensive conclusion about this issue, we performed this meta-analysis. Relevant studies were searched from electronic databases including PubMed, Chinese National Knowledge Infrastructure, Embase, and Wanfang. The strength of correlations was examined with pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). Subgroup analyses stratified by ethnicity and source of control were carried out. All statistical analyses were performed with STATA software (version 12.0). Overall, BMP-14 rs143383 polymorphism was negatively correlated with the susceptibility to knee OA and hand OA under genetic contrasts of CC versus TT, CC + TC versus TT, CC versus TT + TC, C versus T, TC versus TT (OR = 0.71, 95% CI = 0.65–0.79; OR = 0.81, 95% CI = 0.73–0.89; OR = 0.79, 95% CI = 0.71–0.86; OR = 0.85, 95% CI = 0.81–0.90; OR = 0.84, 95% CI = 0.75–0.93), and TC versus TT, CC versus TT + TC, C versus T (OR = 0.76, 95% CI = 0.65–0.89; OR = 0.79, 95% CI = 0.68–0.92; OR = 0.90, 95% CI = 0.85–0.95), respectively; similar results were observed in subgroups after stratification analyses. Additionally, the polymorphism also reduced hip OA risk in Asian group after stratified analysis by ethnicity. BMP-14 rs143383 polymorphism may be a protective factor against OA occurrence.