Patients With Alzheimer Disease Have Altered Transmitral Flow Echocardiographic Analysis of the Vortex Formation Time
Patients With Alzheimer Disease Have Altered Transmitral Flow Echocardiographic Analysis of the Vortex Formation Time
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DOI：
10.7863/jum.2009.28.11.1493
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发表时间：
2009-11-01
影响因子：
2.3
通讯作者：
Roher, Alex E.
中科院分区：
文献类型：
--
作者：
Belohlavek, Marek;Jiamsripong, Panupong;Roher, Alex E.
Objective.有相当多的流行病学证据表明，阿尔茨海默病（AD）与心血管危险因素有关，并与症状性左心室（LV）功能障碍的风险增加有关。在舒张期射流旁边形成涡流意味着有效的血液输送机制。涡流形成时间（VFT）是涡流形成的最佳条件的指标。我们假设AD及其相关的心血管危险因素损害舒张期跨瓣血流效率，因此使VFT值偏离其最佳范围。方法.共对45名参与者进行了超声心动图研究：22名根据美国精神病学协会标准诊断的AD患者和23名年龄匹配的认知功能在正常范围内的对照组。结果与对照组（0.79 +/- 0.14; P = 0.003）相比，AD组（平均值+/- SD，0.67 +/- 14）的左室充盈速度的早期与心房相位的超声心动图比值显著降低。AD组室间隔舒张期厚度、左室后壁舒张期厚度、右室舒张末期内径均显著高于对照组（P
Objective. There is considerable epidemiologic evidence that Alzheimer disease (AD) is linked to cardiovascular risk factors and associated with an increased risk of symptomatic left ventricular (LV) dysfunction. Formation of a vortex alongside a diastolic jet signifies an efficient blood transport mechanism. The vortex formation time (VFT) is an index of optimal conditions for vortex formation. We hypothesized that AD and its associated cardiovascular risk factors impair diastolic transmitral flow efficiency and, therefore, shift the VFT value out of its optimal range. Methods. Echocardiographic studies were performed on 45 participants in total: 22 patients with AD diagnosed according to the American Psychiatric Association's criteria and 23 age-matched individuals as a control group with cognitive function within normal limits. Results. The echocardiographic ratio of the early to atrial phases of the LV filling velocities was significantly lower in the AD group (mean +/- SD, 0.67 +/- 14) when compared with the control individuals (0.79 +/- 0.14; P = .003). The interventricular septum diastolic thickness, left ventricular posterior wall diastolic thickness, and right ventricular end-diastolic diameter were significantly higher in the AD group (P