Stability without a centromere.
Stability without a centromere.
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没有着丝粒的稳定性。
DOI：
10.1073/pnas.95.8.4084
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发表时间：
1998
影响因子：
11.1
通讯作者：
Calos,MP
中科院分区：
文献类型：
--
作者：
Calos,MP
每一条染色体都是珍贵的。每一个都携带着不容丢失的重要遗传信息。为了确保细胞分裂时染色体的保留和分离，纺锤体附着在着丝粒的染色体上。在高等真核生物中，着丝粒是一个很大的区域，通常在哺乳动物染色体中占据一个兆碱基或更多。对于哺乳动物细胞来说，将大量 DNA 用于着丝粒功能并不是问题。它们的基因组中携带数千个兆碱基的 DNA，其中绝大多数不编码蛋白质。但是病毒呢？紧凑性是病毒式传播的策略。如果病毒利用潜伏期的吸引力，留在细胞中直到适合裂解生长的条件，那么它如何才能稳定地留在细胞核中？着丝粒似乎是不可能的。雷曼兄弟 (Lehman) 和 Botchan 在本期的论文中概述了一种不同的策略
Every chromosome is precious. Each one carries vital genetic information that must not be lost. To ensure chromosome retention and segregation when the cell divides, the spindle apparatus attaches to the chromosomes at the centromere. In higher eukaryotes, the centromere is a big region, often occupying a megabase or more in mammalian chromosomes. Dedicating large amounts of DNA to centromere function is not a problem for mammalian cells. They carry thousands of megabases of DNA in their genome, the great majority of which does not code for proteins. But what about a virus? Compactness is the viral strategy. If a virus adopts the attractions of latency, remaining in the cell until conditions are right for lytic growth, how can it stably remain in the nucleus? A centromere seems out of the question. A different strategy is outlined in the paper by Lehman and Botchan in this issue of