Dynamic monitoring of brain activation under visual stimulation using fMRI - The advantage of real-time fMRI with sliding window GLM analysis
Dynamic monitoring of brain activation under visual stimulation using fMRI - The advantage of real-time fMRI with sliding window GLM analysis
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DOI：
10.1016/j.jneumeth.2006.04.017
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发表时间：
2006-10-15
影响因子：
3
通讯作者：
Kato, Chikako
中科院分区：
文献类型：
--
作者：
Nakai, Toshiharu;Bagarinao, Epifanio;Kato, Chikako
应用基于实时分析的功能磁共振成像技术评估基于一般线性模型的t统计量动态监测的优势。用增量分析和滑动窗口分析(SWA)估计四种视觉刺激覆盖不同视野、有无着色时V1和V4的t统计量的时间变化。SWA不仅可视化了激活对任务条件和转换的反应的动态变化，而且使我们能够评估四个视觉区域之间t统计量的时间相关性。提示V4区的活动是双侧组织的，变色刺激对Vi的刺激比黑白刺激更强。虽然每个时间点的激活图代表了几个任务和休息块期间的大脑活动，但SWA将有助于评估神经元对几个连续任务条件的激活转换。增量分析对于在扫描期间实时监控正在进行的激活将是有用的，因为它根据体积数据的累积给出较高的t值。这两种方法是相辅相成的。(C)2006爱思唯尔B.V.保留所有权利。
An fMRI technique based on real-time analysis was applied to evaluate the advantages of dynamic monitoring of the t-statistics based on a general linear model. The temporal change of the t-statistics in V1 and V4 under four conditions of visual stimuli covering different visual fields with or without coloring was estimated using an incremental analysis and a sliding window analysis (SWA). The SWA not only visualized the dynamic change of the activation in response to the task conditions and switching, but also enabled us to evaluate the temporal correlation of the t-statistics among the four visual areas. It was suggested that the activity in the V4 was bilaterally organized, and the altering color stimuli gave stronger stimulation to the V I than did the black and white stimuli. Although the activation map at each time point represents the brain activity during several task and rest blocks, a SWA will be useful to evaluate the transition of neuronal activation in response to several sequential task conditions. An incremental analysis will be useful to monitor the ongoing activation in real-time during the scan, since it gives a higher t-value according to the accumulation of volume data. These two methods will be complementary. (c) 2006 Elsevier B.V. All rights reserved.