The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex
The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex
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DOI：
10.1073/pnas.141218998
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发表时间：
2001-07-03
影响因子：
11.1
通讯作者：
Manning, BH
中科院分区：
文献类型：
--
作者：
Johansen, JP;Fields, HL;Manning, BH
大量的人类和动物研究间接地表明，扣带回前部(ACC)的神经元参与了伤害性感受器刺激的情感后果的编码。然而，还没有提出将行政协调会与这一职能具体联系起来的因果证据。使用结合后爪福尔马林模型和位置条件反射范式的啮齿动物疼痛测试，我们测量了直接反映大鼠疼痛的情感成分(福尔马林诱导的条件性位置回避)的学习行为，同时还测量了反映伤害性刺激强度和位置的“急性”福尔马林诱导的伤害性行为(爪子抬起、舔和退缩)。破坏起源于吻部但不是尾部的神经元，ACC可以减少福尔马林诱导的条件性位置回避，但不会减少急性疼痛相关行为。这些结果提供了证据表明，在伤害感受器刺激的“厌恶”中，ACC中的神经元是必需的。
Numerous human and animal studies indirectly implicate neurons in the anterior cingulate cortex (ACC) in the encoding of the affective consequences of nociceptor stimulation. No causal evidence, however, has been put forth linking the ACC specifically to this function. Using a rodent pain assay that combines the hindpaw formalin model with the place-conditioning paradigm, we measured a learned behavior that directly reflects the affective component of pain in the rat (formalin-induced conditioned place avoidance) concomitantly with "acute" formalin-induced nociceptive behaviors (paw lifting, licking, and flinching) that reflect the intensity and localization of the nociceptive stimulus. Destruction of neurons originating from the rostral, but not caudal, ACC reduced formalin-induced conditioned place avoidance without reducing acute pain-related behaviors. These results provide evidence indicating that neurons in the ACC are necessary for the "aversiveness" of nociceptor stimulation.