COMPARATIVE EFFECTS OF CLARITHROMYCIN AND ERYTHROMYCIN ON THE NORMAL INTESTINAL MICROFLORA
COMPARATIVE EFFECTS OF CLARITHROMYCIN AND ERYTHROMYCIN ON THE NORMAL INTESTINAL MICROFLORA
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DOI：
10.3109/00365549109105189
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发表时间：
1991-01-01
影响因子：
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通讯作者：
NORD, CE
中科院分区：
文献类型：
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作者：
BRISMAR, B;EDLUND, C;NORD, CE
10名健康志愿者口服克拉霉素250 mg，每12 h一次，共7天，另外10名志愿者口服琥乙红霉素1000 mg，每12 h一次，共7天。 在抗生素给药前、给药期间和给药后采集粪便标本。 在克拉霉素组中，需氧微生物中链球菌和肠杆菌的数量减少，而在红霉素组中，抗生素给药期间链球菌、肠球菌和肠杆菌减少，葡萄球菌增加。 厌氧肠道菌群也受到影响。 这些变化在接受红霉素的志愿者中比在接受克拉霉素的志愿者中更明显。
10 healthy volunteers received 250 mg of clarithromycin orally q 12 h for 7 days and 10 other volunteers 1000 mg of erythromycin ethylsuccinate orally q 12 h for 7 days. Stool specimens were collected before, during and after antibiotic administration. In the clarithromycin group, the numbers of streptococci and enterobacteria decreased among aerobic microorganisms while in the erythromycin group streptococci, enterococci and enterobacteria decreased and staphylococci increased during antibiotic administration. The anaerobic intestinal microflora was also affected. The alterations were more pronounced in the volunteers receiving erythromycin than in those having clarithromycin.