Changes in amygdala neural activity that occur with the extinction of context-dependent conditioned fear stress
Changes in amygdala neural activity that occur with the extinction of context-dependent conditioned fear stress
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DOI：
10.1016/j.pbb.2008.02.023
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发表时间：
2008-09-01
影响因子：
3.6
通讯作者：
Koyama, Tsukasa
中科院分区：
文献类型：
--
作者：
Izumi, Takeshi;Inoue, Takeshi;Koyama, Tsukasa
本研究的目的是在大鼠（一种焦虑的动物模型）中，描述伴随情境依赖性条件恐惧压力消失的杏仁核功能变化。具体来说，我们利用免疫组织化学方法研究了条件恐惧诱导的杏仁核中环AMP反应元件结合蛋白（CREB）磷酸化的消失对杏仁核的影响。实验表明，杏仁核基底核的CREB磷酸化随着情境依赖的条件性恐惧诱导的冻结行为的消失而降低。这些数据表明，杏仁核基底核在情境依赖性条件恐惧的表达中起着重要作用。此外，这是第一个证明杏仁核基底核CREB磷酸化与情境依赖性条件恐惧的消失平行变化的研究。(C) 2008爱思唯尔公司版权所有。
The purpose of the present study was to characterize functional changes in the amygdala that accompany the extinction of context-dependent conditioned fear stress in a rat, an animal model of anxiety. Specifically, the effect of extinction of conditioned fear-induced cyclic AMP responsive element-binding protein (CREB) phosphorylation in the amygdala was investigated using immunohistochemistry. Experiments demonstrated that CREB phosphorylation in the basal nucleus of the amygdala decreased with the extinction of context-dependent conditioned fear-induced freezing behavior. These data suggest that the basal nucleus of the amygdala plays an essential role in the expression of context-dependent conditioned fear. Further, this is the first study to demonstrate that CREB phosphorylation in the basal nucleus of the amygdala changes in parallel with the extinction of context-dependent conditioned fear. (C) 2008 Elsevier Inc. All rights reserved.