Studies on the elastic properties of human isolated aorta
Studies on the elastic properties of human isolated aorta
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DOI：
10.1172/jci100886
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发表时间：
1937-07-01
影响因子：
15.9
通讯作者：
Benson, IC
中科院分区：
文献类型：
--
作者：
Hallock, P;Benson, IC
采用所描述的仪器对18例年龄在20-78岁之间的受试者的离体主动脉进行了实验测试，并在一系列曲线中显示了每个年龄组的平均体积弹性特性。平均体积弹性曲线显示动脉刚性随年龄和舒张压的增加而逐渐增加。老年人的主动脉承担了容量储存器的角色，并适应了心输出量的接收，而不会对心脏施加过度的压力，如果弹性组织消失而没有伴随主动脉直径和长度的增加，就会导致这种情况。参考公式[图]，其中v为脉冲波前的速度，单位为米/秒，将该速度与光学记录法获得的体内速度进行比较。本文提出了一种通过与脉搏波速度大致相同的离体主动脉相比较来评估活人主动脉状况的方法。
Eighteen isolated aortas of subjects of from 20-78 years of age were experimentally tested by means of a described apparatus and the mean volume-elasticity characteristics for each age group shown in a series of curves. The mean volume-elasticity curves demonstrate that arterial rigidity increases progressively with age and with increasing diastolic pressure. The aorta of old age assumes the role of a capacity reservoir and becomes adapted to the reception of the cardiac output without imposing an undue strain on the heart, a condition which would otherwise result if the disappearance of elastic tissue occurred without a concomitant increase in the diameter and length of the aorta. By reference to the formula[image] where V. is the velocity of the front of the pulse wave in terms of meters per second, this velocity was compared with the velocity in vivo obtained by the optical record method. A method is shown for evaluating the condition of the aorta in living man by comparison with an isolated aorta having approximately the same pulse wave velocity.