Is skeletal muscle radiodensity able to indicate physical function impairment in older adults with gastrointestinal cancer?
Is skeletal muscle radiodensity able to indicate physical function impairment in older adults with gastrointestinal cancer?
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DOI：
10.1016/j.exger.2019.110688
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发表时间：
2019-10-01
影响因子：
3.9
通讯作者：
Trussardi Fayh, Ana Paula
中科院分区：
文献类型：
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作者：
Barbalho, Erica Roberta;Gonzalez, Maria Cristina;Trussardi Fayh, Ana Paula
背景资料：老年癌症患者的营养状况恶化可能导致肌肉减少症，这是一种与身体功能低下相关的肌肉质量或质量低下的疾病。然而，大多数针对癌症患者的研究仅分析了用于诊断肌肉减少症的肌肉质量的数量，而没有探索肌肉特性和身体功能。本研究的目的是探讨肌肉质量的特点和身体功能之间的关联在老年人cancer.Methods：胃癌老年患者参加了一项横断面研究。腹部区域的计算机断层扫描图像使用Slice-O-Matic 5.0版软件程序（Tomovision，Montreal，Canada）评估骨骼肌质量，以确定骨骼肌指数（SMI，肌肉量）和骨骼肌放射密度（SMD）的参数。通过握力和步行速度测试评价身体功能。四个肌肉组织表型：正常SMI和SMD，只有低SMI，只有低SMD，低SMI和SMD。经年龄和肿瘤分期调整的线性回归分析证实了SMI，SMD和身体功能之间的关联。采用单因素协方差分析和Bonferroni事后检验比较四种不同表型之间的身体功能变量。结果：总共评估了167例患者（58.1%为男性;平均年龄69.17 +/- 7.97岁）。结果表明，肌肉质量特征至少部分地解释了握力和步态速度的直接关系。低肌肉SMI和/或SMD表型在握力和步态速度测试中表现较差。当分层的性别，显着的差异只发生在muscules.Conclusions：低SMD有负面影响的身体功能，在老年人胃肠道癌，特别是在男性。
Background: Worsening nutritional status in older adult cancer patients can lead to sarcopenia, a condition that occurs with low quantity or quality of muscle mass associated with low physical function. However, most of the studies with cancer patients have only analyzed the quantity of muscle mass for diagnostic of sarcopenia, without exploring muscle characteristics and physical function. The purpose of the present study is to explore the associations between muscle mass characteristics and physical function in older adult patients with cancer.Methods: Gastric older cancer patients were enrolled in a cross-sectional study. Computed tomography images of the abdominal region evaluated skeletal muscle mass using the Slice-O-Matic version 5.0 Software program (Tomovision, Montreal, Canada) to determine the parameters of skeletal muscle index (SMI, muscle quantity) and skeletal muscle radiodensity (SMD). The physical function was evaluated through handgrip strength and gait speed test. Four musculature phenotypes were identified: normal SMI and SMD, only low SMI, only low SMD, and low SMI and SMD. Linear regression analyses adjusted by age and tumor stage verified the associations between SMI, SMD and physical function. A One-Way Covariance Analysis with Bonferroni post hoc test was used to compare the physical function variables among the four different phenotypes.Results: In total, 167 patients were evaluated (58.1% males; mean age 69.17 +/- 7.97 years). The results showed that muscle mass characteristics explains, at least partially, the variability in handgrip strength and gait speed in a direct relationship. The phenotypes with low muscular SMI and/or SMD presented worse performances in handgrip strength and gait speed tests. When stratified for sexes, the significant difference occurs only in males.Conclusions: Low SMD has negatively impacted physical function in older adults with gastrointestinal cancer, especially in males.