Conditioned taste aversion: modulation by 5-HT receptor activity and corticosterone
Conditioned taste aversion: modulation by 5-HT receptor activity and corticosterone
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DOI：
10.1016/s0014-2999(03)01790-4
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发表时间：
2003-06-20
影响因子：
5
通讯作者：
Campbell-Meiklejohn, D
中科院分区：
文献类型：
--
作者：
Gorzalka, B;Hanson, L;Campbell-Meiklejohn, D
设计了两个实验，以阐明下丘脑-垂体-肾上腺轴和5-羟色胺(5-HT)系统参与氯化锂条件下味觉厌恶的获得。在实验1中，大鼠每天给予溶剂或50 mg/kg的奈法唑酮，连续4周。用22毫克/公斤的氯化锂处理大鼠，以产生对蔗糖溶液的条件性味觉厌恶。三天后，奈法唑酮完全阻止了氯化锂条件下的味觉厌恶。在实验2中，研究了长期给予皮质酮对氯化锂条件性味觉厌恶的影响。20只雄性大鼠连续14天接受皮质酮(50 mg/kg)或赋形剂注射。在皮质酮治疗的大鼠中，氯化锂条件下的味觉厌恶增强。此外，用皮质酮治疗的动物需要更多的试验才能灭绝。这些结果表明，5-羟色胺系统和下丘脑-垂体-肾上腺轴都参与了氯化锂条件下的味觉厌恶。(C)2003 Elsevier Science B.V.保留所有权利。
Two experiments were designed to elucidate the involvement of the hypothalamic-pituitary-adrenal axis and the 5-hydroxytryptamine (5-HT) system in the acquisition of lithium chloride-conditioned taste aversion. In Experiment 1, rats were administered either vehicle or 50 mg/kg nefazodone daily for 4 weeks. Rats were treated with 22 mg/kg of lithium chloride in order to produce conditioned taste aversion to a sucrose solution. Three days later, nefazodone completely blocked the lithium chloride-conditioned taste aversion. In Experiment 2, the effects of chronic corticosterone administration on lithium chloride-conditioned taste aversion were investigated. Twenty male rats received either corticosterone at a dose of (50 mg/kg) or vehicle injections over a period of 14 consecutive days. Lithium chloride-conditioned taste aversion was potentiated in rats treated with corticosterone. Additionally, corticosterone-treated animals required more trials to reach extinction. These results suggest the involvement of both the 5-HT system and the hypothalamic-pituitary-adrenal axis in lithium chloride-conditioned taste aversion. (C) 2003 Elsevier Science B.V. All rights reserved.