Amphiphilic starlike dextran wrapped superparamagnetic iron oxide nanoparticle clsuters as effective magnetic resonance imaging probes
Amphiphilic starlike dextran wrapped superparamagnetic iron oxide nanoparticle clsuters as effective magnetic resonance imaging probes
复制标题
两亲性星状葡聚糖包裹的超顺磁性氧化铁纳米颗粒簇作为有效的磁共振成像探针
DOI：
10.1016/j.biomaterials.2012.10.056
复制
发表时间：
2013-01-01
期刊：
影响因子：
14
通讯作者：
Ai, Hua
中科院分区：
文献类型：
--
作者：
Su, Hongying;Liu, Yanhong;Ai, Hua
星型聚合物由于其独特的结构和性质，在组织工程、成像、基因和药物传递等领域有着广泛的应用。由于右旋糖酐具有优良的生物相容性，长期以来一直被用作临时血浆替代品。在这项研究中，设计并开发了具有多个葡聚糖臂的星形多糖，通过点击化学将葡聚糖连接到β-环糊精核心。接下来，用脂肪族链修饰星状右旋糖酐，这些两亲聚合物可以在水中自组装成纳米级胶束，并且与其线性类似物（1.7 x 10（-8）M）相比，它们的临界胶束浓度值（3.7 x 10（-8）M）低得多x 10（-7）M），从而在水性环境中形成更稳定的纳米结构。这些胶束可以包封多个超顺磁性氧化铁纳米颗粒并在水中形成簇状颗粒纳米结构，并且所得纳米复合材料在1.51临床磁共振成像（MRI）扫描仪下具有436.8 Fe mM（-1）s（-1）的高T-2弛豫率。此外，通过将超顺磁性氧化铁纳米颗粒和小分子抗癌药物阿霉素装载到聚合物胶束中来开发双功能探针。用这些探针处理的多药耐药乳腺癌细胞MCF-7/Adr可以在MRI下表征。(C)2012爱思唯尔有限公司保留所有权利。
Starlike polymers have been widely used in various fields, such as tissue engineering, imaging, gene and drug delivery because of their unique structures and properties. Dextran has long been used as a temporary plasma substitute because of its excellent biocompatibility. In this study, starlike polysaccharide with multiple dextran arms was designed and developed by attaching dextran to a beta-cyclodextrin core through click chemistry. Next, starlike dextran was modified with aliphatic chains and these amphiphilic polymers can self-assemble into nanoscale micelles in water, and their critical micelle concentration values (3.7 x 10(-8) M) are much lower comparing to its linear analogs (1.7 x 10(-7) M), resulting in more stable nanostructures in aqueous environment. These micelles can encapsulate multiple superparamagnetic iron oxide nanoparticles and forming clustering particle nanostructures in water, and the resulting nanocomposites have a high T-2 relaxivity of 436.8 Fe mM(-1) s(-1) under a 1.51 clinical magnetic resonance imaging (MRI) scanner. Further, dual functional probes were developed by loading both superparamagnetic iron oxide nanoparticles and small molecule anticancer drug doxorubicin into polymeric micelles. Multidrug-resistant breast cancer cells MCF-7/Adr treated with these probes can be characterized under MRI. (C) 2012 Elsevier Ltd. All rights reserved.