Updating contextual information during consolidation as result of a new memory trace
Updating contextual information during consolidation as result of a new memory trace
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DOI：
10.1016/j.nlm.2010.02.004
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发表时间：
2010-05-01
影响因子：
2.7
通讯作者：
Delorenzi, Alejandro
中科院分区：
文献类型：
--
作者：
Daniel Suarez, Luis;Smal, Leticia;Delorenzi, Alejandro
重新整合研究导致了这样一种假设，即当记忆不稳定时，它会被修改以吸收新的信息。这种观点恢复了最初的主张，即短期记忆为有机体提供了一个在储存信息之前评估和重新排列信息的机会，因为它与不稳定的巩固状态同时发生。Chasmagnathus联想记忆模型在这里被用来测试在巩固过程中是否有可能改变最近获得的记忆的某些属性。此外，它是测试行为记忆功能的这些变化是否可以解释为修改巩固的记忆痕迹或作为一个新的记忆痕迹的结果。我们表明，短期记忆是，不像长期记忆，不特定于上下文。在学习后的这段短时间内，行为记忆可以更新，以纳入新的上下文信息。我们发现，在此期间，放线菌酮逆行性遗忘作用可以通过在新的环境中进行一次试验来逆转。最后，通过巩固和再巩固过程中对放线菌酮的记忆敏感性，我们表明，在这个短期记忆期间学习新的上下文（CS）建立了一个新的记忆痕迹，维持行为记忆更新。(C)2010年爱思唯尔公司All rights reserved.
Reconsolidation studies have led to the hypothesis that memory, when labile, would be modified in order to incorporate new information. This view has reinstated original propositions suggesting that short-term memory provides the organism with an opportunity to evaluate and rearrange information before storing it, since it is concurrent with the labile state of consolidation. The Chasmagnathus associative memory model is used here to test whether during consolidation it is possible to change some attribute of recently acquired memories. In addition, it is tested whether these changes in behavioral memory features can be explained as modifications on the consolidating memory trace or as a consequence of a new memory trace. We show that short-term memory is, unlike long-term memory, not context specific. During this short period after learning, behavioral memory can be updated in order to incorporate new contextual information. We found that, during this period, the cycloheximide retrograde amnesic effect can be reverted by a single trial in a new context. Finally, by means of memory sensitivity to cycloheximide during consolidation and reconsolidation, we show that the learning of a new context (CS) during this shortterm memory period builds up a new memory trace that sustains the behavioral memory update. (C) 2010 Elsevier Inc. All rights reserved.