Targeting the synovial tissue for treating osteoarthritis (OA): where is the evidence?
Targeting the synovial tissue for treating osteoarthritis (OA): where is the evidence?
复制标题
DOI：
10.1016/j.berh.2009.08.011
复制
发表时间：
2010-02-01
影响因子：
5.2
通讯作者：
Abramson, Steven B.
中科院分区：
文献类型：
--
作者：
Attur, Mukundan;Samuels, Jonathan;Abramson, Steven B.
骨关节炎（OA）通常是一种进行性和致残性疾病，它发生在各种风险因素的背景下-如年龄增长，肥胖和创伤-这些因素相互勾结，在关节组织内引发一系列病理生理事件。OA的一个重要的新兴主题是将焦点从软骨疾病扩展到“整个关节”疾病。滑膜、骨和软骨都参与了导致关节进行性退化的病理过程。在过去十年中出现的其他主题是软骨降解和修复的新机制，生物力学和生化途径之间的关系，炎症的重要性和遗传学的作用。在这篇文章中，我们回顾了分子，临床和影像学证据，滑膜炎不是一个'偶然发现的ON，但在疾病的发病机制中起着重要作用，因此可能代表未来的治疗目标。(C)2009爱思唯尔有限公司保留所有权利。
Osteoarthritis (OA) is often a progressive and disabling disease, which occurs in the setting of a variety of risk factors - such as advancing age, obesity and trauma - that collude to incite a cascade of pathophysiological events within joint tissues. An important emerging theme in OA is a broadening of focus from a disease of cartilage to one of the 'whole joint.' The synovium, bone and cartilage are each involved in pathological processes that lead to progressive joint degeneration. Additional themes that have emerged over the past decade are novel mechanisms of cartilage degradation and repair, the relationship between biomechanics and biochemical pathways, the importance of inflammation and the role of genetics. In this article, we review the molecular, clinical and imaging evidence that synovitis is not an 'incidental finding of ON, but plays a significant role in disease pathogenesis, and could therefore represent a target for future treatments. (C) 2009 Elsevier Ltd. All rights reserved.