Individual differences in the functional neuroanatomy of inhibitory control
Individual differences in the functional neuroanatomy of inhibitory control
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DOI：
10.1016/j.brainres.2006.03.029
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发表时间：
2006-08-11
期刊：
影响因子：
2.9
通讯作者：
Kelly, Clare
中科院分区：
文献类型：
--
作者：
Garavan, Hugh;Hester, Robert;Kelly, Clare
我们结合了五项与事件相关的反应抑制功能磁共振研究的数据。重新分析(n=71)显示，反应抑制主要由右侧大脑半球的前额叶、顶叶、皮质下和中线区域网络完成，越来越多的证据表明右侧额叶盖的特殊重要性。观察到性别之间的功能差异，在这些皮质区域中，女性的活动量更大。尽管年龄范围相对较窄(18-46岁)，但皮质活动总体上倾向于随着年龄的增长而增加，这与老年人经常观察到的功能招募模式相呼应。心不在焉的受试者在额顶区域表现出更大的活动，而围棋试验的速度反应在更多的后部和皮质下区域产生了不同的激活差异。尽管反应抑制在一个离散的大脑区域网络中产生了强大的激活，但这些结果表明，个体差异影响了该网络节点的相对贡献。(C)2006爱思唯尔B.V.保留所有权利。
We combined the data of five event-related fMRI studies of response inhibition. The reanalysis (n = 71) revealed response inhibition to be accomplished by a largely right hemisphere network of prefrontal, parietal, subcortical and midline regions, with converging evidence pointing to the particular importance of the right frontal operculum. Functional differences were observed between the sexes with greater activity in females in many of these cortical regions. Despite the relatively narrow age range (18-46), cortical activity, on the whole, tended to increase with age, echoing a pattern of functional recruitment often observed in the elderly. More absentminded subjects showed greater activity in fronto-parietal areas, while speed of Go trial responses produced a varied pattern of activation differences in more posterior and subcortical areas. Although response inhibition produces robust activation in a discrete network of brain regions, these results reveal that individual differences impact on the relative contribution made by the nodes of this network. (c) 2006 Elsevier B.V. All rights reserved.