Development of a Standard Reference Material for metabolomics research.
Development of a Standard Reference Material for metabolomics research.
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DOI：
10.1021/ac402689t
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发表时间：
2013-12-17
影响因子：
7.4
通讯作者：
Castle AL
中科院分区：
文献类型：
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作者：
Phinney KW;Ballihaut G;Bedner M;Benford BS;Camara JE;Christopher SJ;Davis WC;Dodder NG;Eppe G;Lang BE;Long SE;Lowenthal MS;McGaw EA;Murphy KE;Nelson BC;Prendergast JL;Reiner JL;Rimmer CA;Sander LC;Schantz MM;Sharpless KE;Sniegoski LT;Tai SS;Thomas JB;Vetter TW;Welch MJ;Wise SA;Wood LJ;Guthrie WF;Hagwood CR;Leigh SD;Yen JH;Zhang NF;Chaudhary-Webb M;Chen H;Fazili Z;LaVoie DJ;McCoy LF;Momin SS;Paladugula N;Pendergrast EC;Pfeiffer CM;Powers CD;Rabinowitz D;Rybak ME;Schleicher RL;Toombs BM;Xu M;Zhang M;Castle AL
美国国家标准与技术研究所（NIST）与美国国立卫生研究院（NIH）合作，开发了一种标准参考物质（SRM），以支持代谢组学研究的技术开发。SRM 1950人血浆代谢物旨在具有代谢物浓度，这些代谢物浓度在成人血浆中具有代表性。用于制备SRM 1950的血浆从男性和女性捐献者中收集，并根据美国人口的种族构成选择捐献者的种族目标。代谢组学研究在仪器和科学目标方面都是多样化的。这个SRM被设计成广泛应用于该领域，而不是针对特定的应用。因此，测定了大约100种分析物的浓度，包括氨基酸、脂肪酸、微量元素、维生素、激素、硒蛋白、临床标志物和全氟化合物（pfc）。值分配测量由NIST和疾病控制与预防中心（CDC）执行。SRM 1950是第一个专门为代谢组学研究开发的参考物质。
The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health (NIH), has developed a Standard Reference Material (SRM) to support technology development in metabolomics research. SRM 1950 Metabolites in Human Plasma is intended to have metabolite concentrations that are representative of those found in adult human plasma. The plasma used in the preparation of SRM 1950 was collected from both male and female donors, and donor ethnicity targets were selected based upon the ethnic makeup of the U.S. population. Metabolomics research is diverse in terms of both instrumentation and scientific goals. This SRM was designed to apply broadly to the field, not toward specific applications. Therefore, concentrations of approximately 100 analytes, including amino acids, fatty acids, trace elements, vitamins, hormones, selenoproteins, clinical markers, and perfluorinated compounds (PFCs), were determined. Value assignment measurements were performed by NIST and the Centers for Disease Control and Prevention (CDC). SRM 1950 is the first reference material developed specifically for metabolomics research.