IMPACT OF TREATING FACILITIES' VOLUME ON SURVIVAL FOR EARLY-STAGE LARYNGEAL CANCER
IMPACT OF TREATING FACILITIES' VOLUME ON SURVIVAL FOR EARLY-STAGE LARYNGEAL CANCER
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DOI：
10.1002/hed.21072
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发表时间：
2009-09-01
影响因子：
2.9
通讯作者：
Ward, Elizabeth
中科院分区：
文献类型：
--
作者：
Chen, Amy Y.;Pavluck, Alex;Ward, Elizabeth
背景。在各种情况下，在大容量设施中进行治疗都可以带来更好的结果。先前尚未研究过喉癌体积与生存率之间的关系。方法。对向国家癌症数据库 (NCDB) 报告的总共 11,446 名早期喉癌患者（1996-1998 年）进行了分析。比例风险回归用于评估生存率和治疗量之间的关系，并控制与生存相关的其他因素。结果。在低容量设施中进行治疗与死亡可能性显着增加相关（风险比 1.20，95% CI 1.04-1.38）。与放射治疗相比，手术切除具有较低的死亡率（HR 0.74，95% CI 0.69-0.80）。结论。这项研究首次评估了喉癌生存率与治疗量之间的关系。在大容量设施中进行治疗可以提高生存率。手术治疗而不是放射治疗也与更好的生存相关，尽管我们无法控制可能导致治疗选择偏差的混杂因素。 (C) 2009 Wiley periodicals, Inc. Head Neck 31: 1137-1143, 2009
Background. Treatment at a high-volume facility has been associated with better outcomes in a variety of conditions. The relationship between volume and survival from laryngeal cancer has not been examined previously.Methods. A total of 11,446 early-stage laryngeal cancer patients (1996-1998) who reported to the National Cancer Database (NCDB) were analyzed. Proportional hazards regression was used to assess the relationship between survival and treatment volume controlling for other factors associated with survival.Results. Treatment at low-volume facilities was associated with a significantly increased likelihood of death (hazard ratio 1.20, 95% CI 1.04-1.38). Surgical resection, as compared with radiation treatment, was associated with lower mortality (HR 0.74, 95% CI 0.69-0.80).Conclusion. This study is the first to assess the relationship between survival and treatment volume in laryngeal cancer. Treatment at a high-volume facility is associated with better survival. Surgical treatment rather than radiation was also associated with better survival, although we could not control for confounders that may bias treatment selection. (C) 2009 Wiley Periodicals, Inc. Head Neck 31: 1137-1143, 2009