Bactericidal and virucidal ultrathin films assembled layer by layer from polycationic N-alkylated polyethylenimines and polyanions.
Bactericidal and virucidal ultrathin films assembled layer by layer from polycationic N-alkylated polyethylenimines and polyanions.
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DOI：
10.1016/j.biomaterials.2010.01.119
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发表时间：
2010-05
期刊：
影响因子：
14
通讯作者：
Sze Yinn Wong;Qing Li;J. Veselinovic;Byeong‐Su Kim;A. Klibanov;P. Hammond
中科院分区：
文献类型：
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作者：
Sze Yinn Wong;Qing Li;J. Veselinovic;Byeong‐Su Kim;A. Klibanov;P. Hammond
在这项工作中，我们设计了接触杀伤离子交联聚合物薄膜，使用逐层（LbL）技术。将具有杀微生物活性的聚阳离子N，N-十二烷基甲基聚乙烯亚胺与聚阴离子（如聚丙烯酸）分层，以产生对空气传播和水传播的大肠杆菌和金黄色葡萄球菌（分别为革兰氏阴性和阳性细菌）以及流感A/WSN（H1N1）病毒高度有效的LbL膜。的杀菌活性的pH值的依赖性LBL膜形成过程中和组装后，聚阳离子和聚阴离子的性质，在LBL膜的层数，和其他实验变量进行了定量研究。
In this work, we designed contact-killing ionically cross-linked polymeric thin films using Layer-by-Layer (LbL) technology. A polycation, N,N-dodecyl,methyl-polyethylenimine, with microbicidal activity was layered with a polyanion, such as poly(acrylic acid), to create LbL films highly effective against both airborne and waterborne Escherichia coli and Staphylococcus aureus (Gram negative and positive bacteria, respectively), as well as influenza A/WSN (H1N1) virus. The dependence of the microbicidal activity on the pH during and post-assembly of LbL film formation, the nature of the polycation and polyanion, the number of layers in the LbL film, and other experimental variables was investigated quantitatively.