Internal desynchronisation of bilaterally organised circadian oscillators in the visual system of insects
Internal desynchronisation of bilaterally organised circadian oscillators in the visual system of insects
复制标题
昆虫视觉系统中双边组织昼夜节律振荡器的内部去同步
作者：
W. K. Koehler;G. Fleissner
多细胞生物体的许多功能都遵循这样一种一致的日常周期性，即使在恒定的环境条件下，也是如此，因此很自然地假设由一个单一的内部时钟控制。但是，一些观察结果只能通过几个昼夜节律调节器的联合作用来解释1，2。实验证实了这样一个系统已经获得了几个species 3，4。例如，生物体中的两种节律可能具有独立的周期长度，即使在稳定状态下也是如此。当两种节律之间的相位差超过360°时，这种内部去极化被认为已经得到证实（参考文献5）。它已被描述为人类1和非人类灵长类动物6。双边对称的后生动物拥有成对的器官表明多振荡器组织的解剖学基础。然而，到目前为止，证据是基于外科手术分离的软体动物7和甲壳动物8的振荡器，或间接对昆虫的消融实验9 -11。我们现在已经获得了甲虫的直接证据，通过证明复眼中右和左敏感性节律之间的内部去极化，而无需手术干预。
MANY functions of multicellular organisms follow such a consistent daily periodicity, even in constant environmental conditions, that it has been natural to postulate control by a single internal clock. But some observations are explained only by the joint action of several circadian oscillators1,2. Experimental confirmation of such a system has been obtained for several species3,4. For example, two rhythms in an organism may have independent period lengths, even in steady state. This internal desynchronisation is thought to have been demonstrated when the phase difference between the two rhythms exceeds 360° (ref. 5). It has been described for humans1 and non-human primates6. The possession of pairs of organs by bilaterally symmetrical metazoans suggests an anatomical basis for multioscillator organisation. So far, however, evidence has been based on surgical isolation of the oscillators of molluscs7 and crustaceans8, or indirectly on ablation experiments with insects9–11. We have now obtained direct evidence with beetles, by demonstrating internal desynchronisation between the right and left sensitivity rhythms in the compound eyes, without surgical intervention.