Two-detector Corrected Near Infrared Spectroscopy (C-NIRS) detects hemodynamic activation responses more robustly than single-detector NIRS
Two-detector Corrected Near Infrared Spectroscopy (C-NIRS) detects hemodynamic activation responses more robustly than single-detector NIRS
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DOI：
10.1016/j.neuroimage.2011.01.043
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发表时间：
2011-04-15
期刊：
影响因子：
5.7
通讯作者：
Berger, Andrew J.
中科院分区：
文献类型：
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作者：
Saager, Rolf B.;Telleri, Nicole L.;Berger, Andrew J.
在人类大脑血流动力学的近红外光谱 (NIRS) 中，刺激相关反应的检测因大脑和覆盖头皮中存在不相关的趋势而混淆。提出的减少血流动力学噪声的策略是通过第二个较短间隔探测器（类似于 5 毫米而不是类似于 30 毫米）同时记录“仅头皮”趋势并执行减法（C-NIRS，“校正近红外光谱”）。为了比较单探测器和双探测器策略，我们对 21 名志愿者进行了视觉刺激反应研究（每次测量运行 6 个刺激块和 8 个记录通道）。激活标记通道的定义基于 (a) 氧合血红蛋白浓度平均上升的显着性（p 值）和 (b) 6 个刺激时期的平均信噪比。在合理的阈值（p < 0.025，SNR > 1）下，C-NIRS 方法将激活标记通道的数量从 47 个增加到 66 个，增加了 40%，增加了 24 个通道，仅消除了 5 个通道。在至少一种模式标记激活的 71 个通道中，C-NIRS 时间序列在 80% 的此类通道中表现出更显着的氧合血红蛋白升高，以及更好的信噪比73%。此外，在六个刺激时期内，单个受试者的 C-NIRS 刺激反应比 NIRS 更一致，幅度和潜伏期（即刺激开始和最大血红蛋白上升之间的时间）的变异系数显着较低。这些结果表明，双探测器 C-NIRS 提供了一种直接的方法：(a) 消除 NIRS 数据中的血流动力学干扰，(b) 提高大脑独特反应的检测率，以及 (c) 提高这些记录反应的质量。关于脱氧血红蛋白趋势的并行见解无法从该数据集中得出，但应该可以在未来具有更高信噪比的研究中获得。 (C) 2011 Elsevier Inc. 保留所有权利。
In near-infrared spectroscopy (NIRS) of human cerebral hemodynamics, detection of stimulus-related responses is confounded by the presence of unrelated trends in both the brain and the overlying scalp. A proposed strategy for reducing hemodynamic noise has been to record "scalp only" trends simultaneously via a second shorter-separation detector (similar to 5 mm rather than similar to 30 mm) and perform a subtraction (C-NIRS, for "corrected near-infrared spectroscopy"). To compare the single- and dual-detector strategies, a 21-volunteer study of visual stimulation responses (6 stimulation blocks and 8 recording channels per measurement run) has been conducted. Activation-flagged channels were defined based upon (a) the significance (p-value) of the average rise in oxyhemoglobin concentration and (b) the average signal-to-noise over 6 stimulation epochs. At reasonable thresholds (p < 0.025, SNR > 1), the C-NIRS method increased the number of activation-flagged channels from 47 to 66, an increase of 40%, adding 24 channels and eliminating only 5. Of the 71 channels that were activation-flagged by at least one modality, the C-NIRS time series exhibited more significant oxyhemoglobin rise in 80% of such channels, and better signal-to-noise in 73%. In addition, single-subject C-NIRS stimulus responses were more consistent than NIRS over the six stimulation epochs, with significantly lower coefficients of variation in both amplitude and latency (i.e. time between stimulus onset and maximum hemoglobin rise). These results demonstrate that two-detector C-NIRS provides a straightforward way of (a) removing hemodynamic interference from NIRS data, (b) increasing the detection rate of cerebrally-unique responses, and (c) improving the quality of those recorded responses. Parallel insights regarding deoxyhemoglobin trends could not be drawn from this data set but should be attainable in future studies with higher signal to noise ratios. (C) 2011 Elsevier Inc. All rights reserved.