Circulating calprotectin as biomarker in neutrophil-related inflammation: Pre-analytical recommendations and reference values according to sample type
Circulating calprotectin as biomarker in neutrophil-related inflammation: Pre-analytical recommendations and reference values according to sample type
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DOI：
10.1016/j.cca.2021.02.022
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发表时间：
2021-03-21
影响因子：
5
通讯作者：
Van Hoovels, Lieve
中科院分区：
文献类型：
--
作者：
Mylemans, Marnix;Nevejan, Louis;Van Hoovels, Lieve
背景：钙保护蛋白（CLP）是评价中性粒细胞相关炎症的一种很有前景的生物标志物。我们的目的是建立不同样品类型循环CLP的参考值，并研究分析前变量的影响。方法：测定100例健康人群的参考值。对10名健康对照者和4名活动性类风湿关节炎患者的分析前变量进行评估，包括样品类型（带/不带凝胶分离器的血清、肝素、EDTA和柠檬酸盐血浆）、预离心时间(
Background: Calprotectin (CLP) is a promising biomarker for the evaluation of neutrophil-related inflammation. Our aim was to establish reference values for circulating CLP in different sample types and to study the effect of pre-analytical variables.Methods: Reference values were determined in 100 healthy individuals. Pre-analytical variables were evaluated in 10 healthy controls and four rheumatoid arthritis patients with active disease and covered sample type (serum with/without gel separator, heparin, EDTA and citrate plasma), pre-centrifugation time (