T-CELLS DISCRIMINATE BETWEEN IA ANTIGENS EXPRESSED ON ALLOGENEIC ACCESSORY CELLS AND B-CELLS - A POTENTIAL FUNCTION FOR CARBOHYDRATE SIDE-CHAINS ON IA MOLECULES
T-CELLS DISCRIMINATE BETWEEN IA ANTIGENS EXPRESSED ON ALLOGENEIC ACCESSORY CELLS AND B-CELLS - A POTENTIAL FUNCTION FOR CARBOHYDRATE SIDE-CHAINS ON IA MOLECULES
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DOI：
10.1073/pnas.80.19.6000
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发表时间：
1983-01-01
期刊：
影响因子：
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通讯作者：
CHAPDELAINE, JM
中科院分区：
文献类型：
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作者：
COWING, C;CHAPDELAINE, JM
从辅助细胞和 B 细胞 Ia 分子获得的肽是相同的，但 α 不同。 B 细胞 Ia 分子链比辅助细胞的链更广泛地唾液酸化。研究旨在确定这种糖基化差异是否可以解释两种细胞类型激活同种异体反应性[小鼠] T 细胞的功能差异。正常静息 B 细胞缺乏诱导同种反应性 T 细胞 DNA 合成或分化的能力。 T 细胞确实能够识别 B 细胞 Ia 分子的多态性，因为它们可以专门为相同单倍型的后续增殖刺激做好准备。 T 细胞的有丝分裂信号由同种异体辅助细胞或神经氨酸酶处理的 B 细胞传递。 T细胞受体可包含α上非多态性脱唾液酸碳水化合物部分的特异性位点。辅助细胞 Ia 分子链。
The peptides obtained from accessory cell and B cell Ia molecules are identical but the .alpha. chains of B cell Ia molecules are more extensively sialylated than those of accessory cells. Studies were designed to determine whether this glycosylation difference can account for the functional difference in the capacity of the 2 cell types to activate alloreactive [mouse] T cells. Normal resting B cells lack the capacity to induce DNA synthesis or differentiation in alloreactive T cells. T cells do recognize polymorphisms in B cell Ia molecules because they can be specifically primed for a subsequent proliferative stimulus of the same haplotype. The mitogenic signal for T cells is delivered by either allogeneic accessory cells or neuraminidase-treated B cells. The T cell receptor(s) may contain a site specific for the nonpolymorphic asialocarbohydrate moiety on the .alpha. chains of accessory cell Ia molecules.