Sigmar1's Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology.
Sigmar1's Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology.
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DOI：
10.3389/fphys.2021.705575
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发表时间：
2021
影响因子：
4
通讯作者：
Bhuiyan MS
中科院分区：
文献类型：
--
作者：
Aishwarya R;Abdullah CS;Morshed M;Remex NS;Bhuiyan MS
Sigmar 1受体（Sigmar 1）是一种广泛表达的多功能细胞器间信号分子伴侣蛋白，在细胞存活中发挥多种作用。Sigmar 1的隐性突变已被确定为神经元和神经肌肉疾病的致病基因。自40多年前发现以来，Sigmar 1已被证明有助于许多细胞功能，包括离子通道调节，蛋白质质量控制，内质网-线粒体通讯，脂质代谢，线粒体功能，自噬激活，并参与细胞存活。Sigmar 1的亚细胞定位、表达和信号传导的改变与多种疾病的进展有关，例如神经退行性疾病、缺血性脑损伤、心血管疾病、糖尿病视网膜病变、癌症和药物成瘾。本文综述了Sigmar 1的分子、细胞、病理生理和生物学功能的研究进展。
The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in Sigmar1 have been identified as a causative gene for neuronal and neuromuscular disorder. Since the discovery over 40 years ago, Sigmar1 has been shown to contribute to numerous cellular functions, including ion channel regulation, protein quality control, endoplasmic reticulum-mitochondrial communication, lipid metabolism, mitochondrial function, autophagy activation, and involved in cellular survival. Alterations in Sigmar1’s subcellular localization, expression, and signaling has been implicated in the progression of a wide range of diseases, such as neurodegenerative diseases, ischemic brain injury, cardiovascular diseases, diabetic retinopathy, cancer, and drug addiction. The goal of this review is to summarize the current knowledge of Sigmar1 biology focusing the recent discoveries on Sigmar1’s molecular, cellular, pathophysiological, and biological functions.
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