Association Between Body Weight and Telomere Length Is Predominantly Mediated Through C-Reactive Protein
Association Between Body Weight and Telomere Length Is Predominantly Mediated Through C-Reactive Protein
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DOI：
10.1210/clinem/dgab455
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发表时间：
2021-06-21
影响因子：
5.8
通讯作者：
Chen, Wei
中科院分区：
文献类型：
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作者：
Gao, Xiao;Li, Shengxu;Chen, Wei
背景：肥胖和炎症都与加速衰老有关。目前尚不清楚炎症是否介导肥胖对衰老的影响。 目的：本研究旨在剖析体重指数（BMI）的直接影响及其通过 C 反应蛋白（CRP）对白细胞端粒长度（LTL）的间接影响，以确定 CRP 对 BMI-LTL 关联的中介作用。 方法：研究队列包括 5451 名成年人（1404 名墨西哥裔美国人、3114 名白人和 933 名黑人） 1999 年至 2002 年全国健康和营养调查显示，男性占 53.5%；平均年龄为 49.2 岁。采用一般中介模型检验CRP对BMI-LTL关联的中介作用。结果：调整年龄、种族、性别、体力活动、饮酒和血清可替宁后，BMI对LTL的总影响显着（标准化回归系数，β=-.054，P
Context: Both obesity and inflammation are related to accelerated aging. It is not yet known whether inflammation mediates the effects of obesity on aging.Objective: This work aims to dissect the direct effect of body mass index (BMI) and its indirect effect through C-reactive protein (CRP) on leukocyte telomere length (LTL) to determine the mediation effect of CRP on the BMI-LTL association.Methods: The study cohort included 5451 adults (1404 Mexican American, 3114 White, and 933 Black individuals; 53.5% male; mean age=49.2 years) from the 1999 to 2002 National Health and Nutrition Examination Survey. General mediation models were used to examine the mediation effect of CRP on the BMI-LTL association.Results: After adjusting for age, race, sex, physical activity, alcohol use, and serum cotinine, the total effect of BMI on LTL was significant (standardized regression coefficient, beta=-.054, P