RECOMBINANT HUMAN-TUMOR NECROSIS FACTOR-ALPHA - EFFECTS ON PROLIFERATION OF NORMAL AND TRANSFORMED-CELLS INVITRO
RECOMBINANT HUMAN-TUMOR NECROSIS FACTOR-ALPHA - EFFECTS ON PROLIFERATION OF NORMAL AND TRANSFORMED-CELLS INVITRO
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DOI：
10.1126/science.3933111
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
SHEPARD, HM
中科院分区：
文献类型：
--
作者：
SUGARMAN, BJ;AGGARWAL, BB;SHEPARD, HM
Modulation of the growth of human and murine cell lines in vitro by recombinant human tumor necrosis factor-.alpha. (rTNF-.alpha.) and recombinant human interferon-.gamma. (rIFN-.gamma.) was investigated. rTNF-.alpha. had cytostatic or cytolytic effects on only some tumor cell lines. When administered together with rIFN-.gamma., rTNF-.alpha. showed enhanced antiproliferative effects on a subset of the cell lines tested. In contrast to its effects on sensitive tumor cells, rTNF-.alpha. augmented the growth of normal diploid fibroblasts. Variations in the proliferative response induced by rTNF-.alpha. were apparently not due to differences in either the number of binding sites per cell or their affinity for rTNF-.alpha.. These observations indicate that the effects of rTNF-.alpha. on cell growth are not limited to tumor cells, but rather that this protein may have a broad spectrum of activities in vivo.
