Plasma B-Type Natriuretic Peptide Levels and Recurrent Arrhythmia After Successful Ablation of Lone Atrial Fibrillation
Plasma B-Type Natriuretic Peptide Levels and Recurrent Arrhythmia After Successful Ablation of Lone Atrial Fibrillation
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DOI：
10.1161/circulationaha.110.007252
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发表时间：
2011-05-17
期刊：
影响因子：
37.8
通讯作者：
Wazni, Oussama M.
中科院分区：
文献类型：
--
作者：
Hussein, Ayman A.;Saliba, Walid I.;Wazni, Oussama M.
背景：孤立性心房颤动（AF）患者血浆B型利钠肽（BNP）异常升高。这种升高的确切意义和预后意义尚未确定。对于接受心律失常消融术的孤立性房颤患者的BNP知之甚少。我们试图确定BNP水平和孤立性AF消融后心律失常复发风险之间的关系。方法和结果-我们随访了726例孤立性AF患者接受首次心律失常消融。所有患者均在消融当天使用床旁分类仪测定（Biosite Diagnostics，San Diego，CA）测量BNP水平。在基线时，多变量线性回归分析中与BNP水平升高相关的因素（以BNP对数为因变量）是年龄较大（+1年变化的β回归系数为0.025; P
Background-Plasma B-type natriuretic peptide (BNP) is abnormally elevated in patients with lone atrial fibrillation (AF). The exact significance and prognostic implications of this elevation have yet to be determined. Little is known about BNP in lone AF patients undergoing arrhythmia ablation. We sought to determine the relationship between BNP levels and the risk of recurrent arrhythmia after ablation of lone AF.Methods and Results-We followed up 726 patients with lone AF undergoing first-time arrhythmia ablation. All had BNP levels measured on the day of ablation with of the point-of-care Triage Meter assay (Biosite Diagnostics, San Diego, CA). At baseline, factors associated with elevated BNP levels in multivariable linear regression analysis (with log BNP being the dependent variable) were older age (beta regression coefficient for +1-year change, 0.025; P