Frequency and type of reactions to antituberculosis drugs: Observations in routine treatment
Frequency and type of reactions to antituberculosis drugs: Observations in routine treatment
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DOI：
10.1016/s0962-8479(96)90073-8
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发表时间：
1996-02-01
期刊：
影响因子：
--
通讯作者：
Horsfield, N
中科院分区：
文献类型：
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作者：
Ormerod, LP;Horsfield, N
设定：United Kingdom，1978- 1992.目的：评估抗结核药物反应的发生率和类型，研究一系列患者的抗结核药物反应。设计：所有接受结核病治疗的患者都有详细的药物治疗、持续时间和需要改变治疗的副作用。对1978-1980例患者的数据进行回顾性汇编，并在此后进行前瞻性汇编。药物反应的分析是由药物，总月药物使用，年龄，性别和种族，反应type.Results：1317例患者67（5.1%）有70个抗结核药物反应需要修改的治疗。药物反应的频率从0-19岁的2.3%增加到20-39岁的4.6%，40-59岁的7.1%，60岁及以上的8.4%。女性的反应率显著高于男性。白色患者有较高的反应率比巴基斯坦和印度的患者，主要是由于平均年龄被great.Conclusion：在这个很大程度上前瞻性研究的药物反应率为5.1%，低于在英国和其他国家的其他研究系列报道。
Setting: United Kingdom, 1978-1992.Objective: To assess the incidence and type of reactions to antituberculosis drugs in an unselected series of patients.Design: All patients treated for tuberculosis had details of drug treatment, durations and side-effects requiring alteration of treatment available. The data was compiled retrospectively for 1978-1980 patients and prospectively thereafter. Analysis of drug reactions was by drug, total months drug use, by age, sex and ethnic group, and reaction type.Results: Of 1317 patients 67 (5.1%) had 70 reactions to antituberculosis drugs requiring modification of treatment. The frequency of drug reactions increased from 2.3% at age 0-19 to 4.6% at age 20-39, 7.1% for age 40-59 and to 8.4% for those aged 60 and over. Females had significantly higher reactions rates than males. White patients had higher reaction rates than Pakistani and Indian patients, mainly due to the average age being greater.Conclusion: The drug reaction rate of 5.1% in this largely prospective study is lower than that reported in other unselected series in the UK and other countries.