Effect of 1 alpha-vitamin D-3 and estrogen therapy on cortical bone mechanical properties in the ovariectomized rat model
Effect of 1 alpha-vitamin D-3 and estrogen therapy on cortical bone mechanical properties in the ovariectomized rat model
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DOI：
10.1210/en.137.4.1358
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发表时间：
1996-04-01
期刊：
影响因子：
4.8
通讯作者：
Dequeker, J
中科院分区：
文献类型：
--
作者：
Aerssens, J;VanAudekercke, R;Dequeker, J
有充分的证据表明，1 α-维生素D-3治疗可以增加卵巢切除大鼠的骨量和大小。这种疗法对骨机械能力的影响还远不清楚。因此，本研究的目的是检查接受雌激素（0.25 mg/kg .周）和/或1 α-维生素D-3（0.5 μ kg .天）。在卵巢切除术后立即开始或3个月后开始的6个月内给予药物。进行扭转试验，从中推导出参数强度、刚度、最大角位移和能量吸收能力（韧性）。生成多元回归模型以估计治疗对骨力学性质的相对重要性。骨硬度随年龄增长而增加。卵巢切除术改善骨力学参数，直到6个月后卵巢切除术，而雌激素治疗导致类似的机械性能，在完整的年龄匹配的控制。在1 α-维生素D-3治疗后观察到所有机械参数的显著改善。1 α-维生素D-3和雌激素的联合治疗不如1 α-维生素D-3单独治疗有效，但优于雌激素单独治疗，表明两种治疗之间的相互作用。我们的结论是，1 α-维生素D-3治疗卵巢切除大鼠改善骨机械能力，这可能是部分相关的骨量和大小的改变。
It is well documented that both bone mass and size of ovariectomized rats can be increased by 1 alpha-vitamin D-3 therapy. The repercussion of this therapy on bone mechanical competence is far less clear. Therefore, the objective of this study was to examine the mechanical properties of the shaft femur in ovariectomized rats (3 months old) receiving estrogen (0.25 mg/kg . week) and/or 1 alpha-vitamin D-3 (0.5 mu kg . day). The medication was given during 6 months starting immediately after ovariectomy or starting 3 months later. Torsional testing was performed from which the parameters strength, stiffness, maximum angular displacement, and energy absorbing capacity (toughness) were derived. Multiple regression models were generated to estimate the relative importance of the therapies on bone mechanical properties. Bone stiffness increased with age. Ovariectomy improved bone mechanical parameters until 6 months postovariectomy, whereas estrogen treatment resulted in similar mechanical properties as those in intact age-matched controls. A significant improvement of all mechanical parameters was observed after 1 alpha-vitamin D-3 therapy. The combined therapy of 1 alpha-vitamin D-3 and estrogen was less effective than 1 alpha-vitamin D-3 alone, but better than estrogen therapy alone, suggesting interactive effects between both therapies. We conclude that 1 alpha-vitamin D-3 treatment of ovariectomized rats improves bone mechanical competence, which might be partially related to alterations in both bone mass and size.