Calcium‐activated membrane depolarization via modulation of chloride efflux from parietal cells during gastrin stimulation
Calcium‐activated membrane depolarization via modulation of chloride efflux from parietal cells during gastrin stimulation
复制标题
在胃泌素刺激过程中通过调节壁细胞氯离子流出来实现钙激活膜去极化
DOI：
10.1016/0014-5793(87)80209-0
复制
发表时间：
1987
期刊：
影响因子：
3.5
通讯作者：
H. Matsumiya
中科院分区：
文献类型：
--
作者：
Y. Tsunoda;H. Matsumiya
In the isolated parietal cell the following observations were made: gastrin led to an increase in cytoplasmic free Ca2+concentration ([Ca2+]i) even in the absence of medium Ca2+and to transient membrane depolarization in both the absence of the medium Ca2+and the fura‐2‐loaded cell. The incorporated Ca2+chelator BAPTA inhibited the gastrin‐induced membrane depolarization. The magnitude of depolarization caused by gastrin was unchanged on removal of medium Na+. Furosemide but not tetraethylammonium inhibited the gastrin‐induced depolarization. The results suggest that the Ca2+released from the store(s) induces membrane depolarization, possibly via modulation of a Cl−efflux across the luminal surface during gastrin stimulation.
DOI：
--
发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Cuppoletti,J;Sachs,G
通讯作者：
Sachs,G