Apolipoprotein E ε4 allele frequency in vascular dementia
Apolipoprotein E ε4 allele frequency in vascular dementia
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DOI：
10.1159/000092960
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发表时间：
2006-01-01
影响因子：
2.4
通讯作者：
Mann, David M. A.
中科院分区：
文献类型：
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作者：
Davidson, Yvonne;Gibbons, Linda;Mann, David M. A.
目的：探讨载脂蛋白E(ApoE)基因epsilon 4等位基因是否会增加患血管性痴呆(Vad)的风险。方法：采用聚合酶链式反应(PCR法)检测组和97例发病年龄、民族背景相近的疑似阿尔茨海默病(AD)患者的载脂蛋白E等位基因和基因型频率，并与来自同一地区的766例对照组进行比较。结果：97例疑似AD患者APOE epsilon 4等位基因频率均显著高于对照组(P<0.001)。然而，89例可能和可能的VaD患者的apoE epsilon 4等位基因频率也显著高于正常对照组(P<0.001)，但与AD组无显著差异。当只考虑那些可能患有AD或可能的VAD的患者时，apoE epsilon 4等位基因频率类似，并且仍然显著增加(p<；0.001)。结论：APOE epsilon 4等位基因的存在增加了VaD的风险。版权所有(C)2006 S.Karger AG，巴塞尔。
Aim: The aim of the study was to investigate whether possession of the epsilon 4 allelic form of the apolipoprotein E (APOE) gene increases the risk of developing vascular dementia (VaD). Methods: APOE allele and genotype frequencies were determined by PCR in 89 patients with possible and probable VaD and compared with those in 97 patients with possible and probable Alzheimer's disease (AD) of similar age of disease onset and ethnic background, and with 766 control subjects drawn from the same geographical region. Results: The APOE epsilon 4 allele frequency in all 97 patients with possible and probable AD was significantly higher ( p < 0.001) than that in control subjects. However, the APOE epsilon 4 allele frequency in all 89 patients with possible and probable VaD was also significantly higher ( p < 0.001) than that in control subjects, but not significantly different from that in AD. The APOE epsilon 4 allele frequency was similarly, and still significantly ( p < 0.001), increased when only those patients with probable AD or probable VaD were considered. Conclusion: Possession of APOE epsilon 4 allele increases the risk of VaD. Copyright (C) 2006 S. Karger AG, Basel.