Acute effects of dietary protein on food intake, tissue amino acids, and brain serotonin.
Acute effects of dietary protein on food intake, tissue amino acids, and brain serotonin.
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膳食蛋白质对食物摄入、组织氨基酸和大脑血清素的急性影响。
DOI：
10.1152/ajpregu.1987.252.5.r902
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Harper,AE
中科院分区：
文献类型：
--
作者：
Peters,JC;Harper,AE
先前适应20％酪蛋白饮食的雄性大鼠(100g)被喂食含有0至55％酪蛋白的饮食，并在20、60、150、240或330分钟后处死。喂食无蛋白质饮食或含有超过 35% 酪蛋白的饮食的大鼠的食物摄入量在 20 分钟内下降，并持续下降长达 5.5 小时。喂食无蛋白饮食的大鼠的食物摄入量减少伴随着血浆和脑中游离不可缺少氨基酸（IAA）总浓度的迅速降低。与饲喂含有 15-20% 酪蛋白的饮食的动物相比，饲喂含有超过 35% 酪蛋白的饮食的组的食物摄入量下降与血浆和大脑总 IAA 浓度升高相关。在食物或蛋白质摄入量与 5-羟色胺、5-羟基吲哚-3-乙酸或其总和的全脑浓度之间没有观察到一致的关系。我们的结果表明，在单一饮食喂养的动物中，如果大脑中游离IAA的总浓度低于某个临界最小值或超过某个最大可耐受水平，食物摄入量就会减少。
Male rats (100 g) previously adapted to a 20% casein diet were fed diets containing from 0 to 55% of casein and were killed after 20, 60, 150, 240, or 330 min. Food intake of rats fed a protein-free diet or a diet containing greater than 35% of casein was depressed within 20 min and remained depressed for up to 5.5 h. Depressed food intake of rats fed protein-free diets was accompanied by a rapid reduction in plasma and brain total concentrations of free indispensable amino acids (IAA). Food intake depression among groups fed diets containing in excess of 35% casein was associated with elevated plasma and brain total IAA concentrations, compared with those of animals fed diets containing 15-20% of casein. No consistent relationships were observed between food or protein intakes and whole-brain concentrations of 5-hydroxytryptamine, 5-hydroxyindole-3-acetic acid, or their sum. Our results suggest that in animals fed a single diet, food intake is depressed if the total concentration of free IAA in brain either falls below a certain critical minimum or exceeds some maximum tolerable level.