Localized Delivery of Theranostic Nanoparticles and High-Energy Photons using Microneedles-on-Bioelectronics
Localized Delivery of Theranostic Nanoparticles and High-Energy Photons using Microneedles-on-Bioelectronics
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DOI：
10.1002/adma.202100425
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发表时间：
2021-05-06
影响因子：
29.4
通讯作者：
Kim, Dae-Hyeong
中科院分区：
文献类型：
--
作者：
Lee, Youngsik;Kang, Taegyu;Kim, Dae-Hyeong
由于血脑屏障，光响应治疗诊断纳米颗粒（NP）对靶向肿瘤部位，特别是对脑肿瘤的低递送效率一直是基于NP的癌症治疗中的关键问题。此外，可以有效地激活治疗诊断NP的高能光子由于这种光子在穿透周围组织时的强散射而几乎不能被递送到目标区域。在这里，介绍了一种使用微针生物电子学将治疗诊断NP和高能光子局部递送到靶肿瘤的方法。将两种类型的微针和柔性生物电子集成并安装在手术钳的边缘。含有治疗诊断NP的生物可吸收微针将NP递送到靶肿瘤（例如，胶质母细胞瘤、垂体腺瘤）。磁共振成像可以定位NPs。然后，光导/扩散微针将高能光子从生物电子器件传递到NP。高能光子激活纳米粒子通过光动力学疗法和化学疗法治疗肿瘤组织。生物电子学的受控热驱动加速了化学药物的扩散。所提出的方法是证明与小鼠肿瘤模型在体内。
The low delivery efficiency of light-responsive theranostic nanoparticles (NPs) to target tumor sites, particularly to brain tumors due to the blood-brain barrier, has been a critical issue in NP-based cancer treatments. Furthermore, high-energy photons that can effectively activate theranostic NPs are hardly delivered to the target region due to the strong scattering of such photons while penetrating surrounding tissues. Here, a localized delivery method of theranostic NPs and high-energy photons to the target tumor using microneedles-on-bioelectronics is presented. Two types of microneedles and flexible bioelectronics are integrated and mounted on the edge of surgical forceps. Bioresorbable microneedles containing theranostic NPs deliver the NPs into target tumors (e.g., glioblastoma, pituitary adenoma). Magnetic resonance imaging can locate the NPs. Then, light-guiding/spreading microneedles deliver high-energy photons from bioelectronics to the NPs. The high-energy photons activate the NPs to treat tumor tissues by photodynamic therapy and chemotherapy. The controlled thermal actuation by the bioelectronics accelerates the diffusion of chemo-drugs. The proposed method is demonstrated with mouse tumor models in vivo.