Clinical indices of familial depression in the Swedish Twin Registry
Clinical indices of familial depression in the Swedish Twin Registry
复制标题
DOI：
10.1111/j.1600-0447.2006.00863.x
复制
发表时间：
2007-03-01
影响因子：
6.7
通讯作者：
Pedersen, N. L.
中科院分区：
文献类型：
--
作者：
Kendler, K. S.;Gatz, M.;Pedersen, N. L.
目的：虽然家族性因素肯定有助于重度抑郁症（MD）的病因学，但还需要进一步的信息来了解抑郁症的哪些临床特征是家族性易感性的指标。方法：通过个人访谈对27230对双胞胎进行终身MD和相关临床特征的评估，其中包括来自瑞典国家双胞胎登记处的4080例MD发病。采用Cox比例风险模型进行分析。结果：抑郁双胞胎的三个临床变量预测双胞胎患MD的风险比。按照关联强度的顺序，这些是：认可的A标准的数量、发病年龄和发作次数。结论：MD的某些临床特征是家族性MD易感性的重要指标，尽管不明显。家族/遗传风险高的个体往往发病年龄早，符合大多数症状性DSM标准，并且容易复发。
Objective: Although familial factors certainly contribute to the etiology of major depression (MD), further information is needed about which clinical features of depressive illness index the familial vulnerability in MD.Method: Lifetime MD and associated clinical features were assessed at personal interview in 27 230 individual twins, including 4080 onsets of MD, from the Swedish National Twin Registry. Analyses were conducted using Cox proportional hazards models.Results: Three clinical variables in a depressed twin predicted the hazard ratio for MD in the cotwin. In the order of the strength of the association, these were: number of endorsed A criteria, age at onset, and number of episodes.Conclusion: Certain clinical features of MD are significant, albeit modest, indices of the familial vulnerability to MD. Individuals with a high familial/genetic risk for MD tend to have an early age at onset, meet most of the symptomatic DSM criteria and suffer recurrences.